ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	WWP1
Symbol Alias	AIP5, DKFZP434D2111
Approved Name	WW domain containing E3 ubiquitin protein ligase 1
Location	8q21
Position	chr8:87354967-87490649, +
External Links	HGNC: 17004 Entrez Gene: 11059 Ensembl: ENSG00000123124 UCSC: uc003ydt.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_6	chr8:85438801-88424995 (NCBI Build 36.1 (hg18))	2935186	8q21.2-8q21.3	Loss	Paternal

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 14)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0046718	viral entry into host cell	Biological Process	TAS[12450395]	2
GO:0043161	proteasomal ubiquitin-dependent protein catabolic process	Biological Process		16
GO:0045892	negative regulation of transcription, DNA-dependent	Biological Process		64
GO:0016567	protein ubiquitination	Biological Process	TAS[12535537]	41
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Biological Process		16
GO:0007165	signal transduction	Biological Process	NAS[9169421]	171
GO:0007417	central nervous system development	Biological Process	NAS[9647693]	22
GO:0005886	plasma membrane	Cellular Component		772
GO:0005829	cytosol	Cellular Component		447
GO:0005737	cytoplasm	Cellular Component		690
GO:0005634	nucleus	Cellular Component		770
GO:0005515	protein binding	Molecular Function	IPI[19447967]	910
GO:0004842	ubiquitin-protein ligase activity	Molecular Function	TAS[9169421]	52
GO:0000151	ubiquitin ligase complex	Cellular Component	NAS[9169421]	15

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04144	Endocytosis	39	Endocytosis is a mechanism for cells to remove ligands, nutr...... Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type. More...
hsa04120	Ubiquitin mediated proteolysis	29	Protein ubiquitination plays an important role in eukaryotic...... Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates. More...

Genes shared at least 5 GO terms with WWP1 (count: 59)

Gene Symbol	Pathway Count	Pathway List
ARRB1	7	proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; plasma membrane; cytosol; cytoplasm; nucleus; protein binding;
ARRB2	7	proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; plasma membrane; cytosol; cytoplasm; nucleus; protein binding;
CBL	7	protein ubiquitination; plasma membrane; cytosol; cytoplasm; nucleus; protein binding; ubiquitin-protein ligase activity;
MALT1	7	protein ubiquitination; plasma membrane; cytosol; cytoplasm; nucleus; protein binding; ubiquitin-protein ligase activity;
NEDD4L	7	protein ubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; cytosol; cytoplasm; nucleus; protein binding; ubiquitin-protein ligase activity;
RCHY1	7	protein ubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; cytoplasm; nucleus; protein binding; ubiquitin-protein ligase activity; ubiquitin ligase complex;
PARK2	7	protein ubiquitination involved in ubiquitin-dependent protein catabolic process; central nervous system development; cytosol; cytoplasm; nucleus; protein binding; ubiquitin-protein ligase activity;
KLHL20	6	proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; cytoplasm; nucleus; protein binding; ubiquitin-protein ligase activity;
GSK3B	6	negative regulation of transcription, DNA-dependent; plasma membrane; cytosol; cytoplasm; nucleus; protein binding;
BARD1	6	protein ubiquitination; cytoplasm; nucleus; protein binding; ubiquitin-protein ligase activity; ubiquitin ligase complex;
HERC2	6	protein ubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; cytoplasm; nucleus; protein binding; ubiquitin-protein ligase activity;
TRIM32	6	protein ubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; cytoplasm; nucleus; protein binding; ubiquitin-protein ligase activity;
TRIP12	6	protein ubiquitination; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; cytoplasm; nucleus; protein binding; ubiquitin-protein ligase activity;
HERC5	6	protein ubiquitination involved in ubiquitin-dependent protein catabolic process; cytosol; cytoplasm; nucleus; protein binding; ubiquitin-protein ligase activity;
UBE3A	6	protein ubiquitination involved in ubiquitin-dependent protein catabolic process; cytosol; cytoplasm; nucleus; protein binding; ubiquitin-protein ligase activity;
AIP	6	signal transduction; plasma membrane; cytosol; cytoplasm; nucleus; protein binding;
PRKCB	6	signal transduction; plasma membrane; cytosol; cytoplasm; nucleus; protein binding;
PRKD1	6	signal transduction; plasma membrane; cytosol; cytoplasm; nucleus; protein binding;
RNF40	6	plasma membrane; cytoplasm; nucleus; protein binding; ubiquitin-protein ligase activity; ubiquitin ligase complex;
BIRC2	5	proteasomal ubiquitin-dependent protein catabolic process; cytosol; nucleus; protein binding; ubiquitin-protein ligase activity;
CRBN	5	proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; cytoplasm; nucleus; protein binding;
DDB1	5	proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; cytoplasm; nucleus; protein binding;
TRIM13	5	proteasomal ubiquitin-dependent protein catabolic process; signal transduction; cytoplasm; protein binding; ubiquitin-protein ligase activity;
DAXX	5	negative regulation of transcription, DNA-dependent; cytosol; cytoplasm; nucleus; protein binding;
HSPA8	5	negative regulation of transcription, DNA-dependent; plasma membrane; cytosol; nucleus; protein binding;
ID2	5	negative regulation of transcription, DNA-dependent; cytosol; cytoplasm; nucleus; protein binding;
MEN1	5	negative regulation of transcription, DNA-dependent; cytosol; cytoplasm; nucleus; protein binding;
PDCD4	5	negative regulation of transcription, DNA-dependent; cytosol; cytoplasm; nucleus; protein binding;
RELA	5	negative regulation of transcription, DNA-dependent; cytosol; cytoplasm; nucleus; protein binding;
STRN3	5	negative regulation of transcription, DNA-dependent; plasma membrane; cytoplasm; nucleus; protein binding;
ZBTB16	5	negative regulation of transcription, DNA-dependent; protein ubiquitination; central nervous system development; nucleus; protein binding;
CUL5	5	protein ubiquitination; plasma membrane; cytosol; nucleus; protein binding;
FBXO25	5	protein ubiquitination; nucleus; protein binding; ubiquitin-protein ligase activity; ubiquitin ligase complex;
FBXO4	5	protein ubiquitination; cytoplasm; protein binding; ubiquitin-protein ligase activity; ubiquitin ligase complex;
RFWD2	5	protein ubiquitination; cytosol; cytoplasm; nucleus; protein binding;
HECTD1	5	protein ubiquitination involved in ubiquitin-dependent protein catabolic process; cytoplasm; nucleus; protein binding; ubiquitin-protein ligase activity;
HERC6	5	protein ubiquitination involved in ubiquitin-dependent protein catabolic process; cytosol; cytoplasm; nucleus; ubiquitin-protein ligase activity;
RNF144B	5	protein ubiquitination involved in ubiquitin-dependent protein catabolic process; cytoplasm; protein binding; ubiquitin-protein ligase activity; ubiquitin ligase complex;
RNF146	5	protein ubiquitination involved in ubiquitin-dependent protein catabolic process; cytosol; nucleus; protein binding; ubiquitin-protein ligase activity;
ADRBK1	5	signal transduction; plasma membrane; cytosol; cytoplasm; protein binding;
APBB1	5	signal transduction; plasma membrane; cytoplasm; nucleus; protein binding;
LPXN	5	signal transduction; plasma membrane; cytoplasm; nucleus; protein binding;
MAPK1	5	signal transduction; cytosol; cytoplasm; nucleus; protein binding;
PRKG1	5	signal transduction; plasma membrane; cytosol; cytoplasm; protein binding;
PYCARD	5	signal transduction; cytosol; cytoplasm; nucleus; protein binding;
GSTP1	5	central nervous system development; cytosol; cytoplasm; nucleus; protein binding;
APC	5	plasma membrane; cytosol; cytoplasm; nucleus; protein binding;
BAIAP2	5	plasma membrane; cytosol; cytoplasm; nucleus; protein binding;
CRYAB	5	plasma membrane; cytosol; cytoplasm; nucleus; protein binding;
CTNND1	5	plasma membrane; cytosol; cytoplasm; nucleus; protein binding;
NCK1	5	plasma membrane; cytosol; cytoplasm; nucleus; protein binding;
PDE2A	5	plasma membrane; cytosol; cytoplasm; nucleus; protein binding;
SNCA	5	plasma membrane; cytosol; cytoplasm; nucleus; protein binding;
STXBP3	5	plasma membrane; cytosol; cytoplasm; nucleus; protein binding;
TJP1	5	plasma membrane; cytosol; cytoplasm; nucleus; protein binding;
WWOX	5	plasma membrane; cytosol; cytoplasm; nucleus; protein binding;
TNFAIP3	5	cytosol; cytoplasm; nucleus; protein binding; ubiquitin-protein ligase activity;
FBXO7	5	cytoplasm; nucleus; protein binding; ubiquitin-protein ligase activity; ubiquitin ligase complex;
PRPF19	5	cytoplasm; nucleus; protein binding; ubiquitin-protein ligase activity; ubiquitin ligase complex;

Genes shared at least 2 KEGG pathways with WWP1 (count: 2)

Gene Symbol	Pathway Count	Pathway List
CBL	2	Endocytosis; Ubiquitin mediated proteolysis;
NEDD4L	2	Endocytosis; Ubiquitin mediated proteolysis;

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Region: chr8:87354967..87490649 View in gBrowse