ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MALT1
Previous Symbol	MLT
Approved Name	mucosa associated lymphoid tissue lymphoma translocation gene 1
Name Alias	paracaspase
Location	18q21
Position	chr18:56338618-56421130, +
External Links	HGNC: 6819 Entrez Gene: 10892 Ensembl: ENSG00000172175 UCSC: uc002lhm.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
18q21.31-21.32	chr18:53800000-59000000	1 (1/0/0)

Gene related GO terms (count: 37)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 37)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005737	cytoplasm	Cellular Component		690
GO:0005829	cytosol	Cellular Component		447
GO:0005886	plasma membrane	Cellular Component		772
GO:0006508	proteolysis	Biological Process	IDA[18223652]	102
GO:0006952	defense response	Biological Process	NAS[10523859]	5
GO:0007250	activation of NF-kappaB-inducing kinase activity	Biological Process	IMP[15125833]	3
GO:0008233	peptidase activity	Molecular Function	IDA[18223652]	15
GO:0009620	response to fungus	Biological Process		1
GO:0002237	response to molecule of bacterial origin	Biological Process		2
GO:0002726	positive regulation of T cell cytokine production	Biological Process	IMP[15125833]	2
GO:0004197	cysteine-type endopeptidase activity	Molecular Function	NAS[11090634]	17
GO:0004842	ubiquitin-protein ligase activity	Molecular Function	IDA[15125833]	52
GO:0004871	signal transducer activity	Molecular Function	IMP[12761501]	49
GO:0005515	protein binding	Molecular Function	IPI[18223652]	910
GO:0005634	nucleus	Cellular Component		770
GO:0005730	nucleolus	Cellular Component		243
GO:0043234	protein complex	Cellular Component	IDA[15125833]	45
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	Biological Process	IMP[12761501]	27
GO:0045087	innate immune response	Biological Process		54
GO:0043621	protein self-association	Molecular Function	IPI[15125833]	8
GO:0050852	T cell receptor signaling pathway	Biological Process	IDA[15125833]	21
GO:0048471	perinuclear region of cytoplasm	Cellular Component		87
GO:0050870	positive regulation of T cell activation	Biological Process	IC[15125833]	3
GO:0050856	regulation of T cell receptor signaling pathway	Biological Process		2
GO:0019209	kinase activator activity	Molecular Function	IMP[15125833]	1
GO:0016567	protein ubiquitination	Biological Process	IDA[15125833]	41
GO:0032449	CBM complex	Cellular Component	NAS[15125833]	1
GO:0031398	positive regulation of protein ubiquitination	Biological Process	NAS[18223652]	8
GO:0042098	T cell proliferation	Biological Process		4
GO:0032743	positive regulation of interleukin-2 production	Biological Process	IMP[15125833]	2
GO:0043066	negative regulation of apoptotic process	Biological Process	NAS[11090634]	77
GO:0042981	regulation of apoptotic process	Biological Process	IDA[12819136]	32
GO:0051259	protein oligomerization	Biological Process	IDA[15125833]	8
GO:0051092	positive regulation of NF-kappaB transcription factor activity	Biological Process	IMP[18223652]	27
GO:0051168	nuclear export	Biological Process	IDA[16123224]	3
GO:0002020	protease binding	Molecular Function		13
GO:0001923	B-1 B cell differentiation	Biological Process		1

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04662	B cell receptor signaling pathway	14	B cells are an important component of adaptive immunity. The...... B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor (BCR) is an integral membrane protein complex that is composed of two immunoglobulin (Ig) heavy chains, two Ig light chains and two heterodimers of Ig-alpha and Ig-beta. After BCR ligation by antigen, three main protein tyrosine kinases (PTKs) -the SRC-family kinase LYN, SYK and the TEC-family kinase BTK- are activated. Phosphatidylinositol 3-kinase (PI3K) and phospholipase C-gamma 2 (PLC-gamma 2) are important downstream effectors of BCR signalling. This signalling ultimately results in the expression of immediate early genes that further activate the expression of other genes involved in B cell proliferation, differentiation and Ig production as well as other processes. More...
hsa05152	Tuberculosis	30	Tuberculosis, or TB, is an infectious disease caused by Myco...... Tuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent infections, and about 10% of latent infections develop active diseases when their immune system is impaired due to the age, other diseases such as AIDS or exposure to immunosuppressive drugs. TB is transmitted through the air and primarily attacks the lungs, then it can spread by the circulatory system to other parts of body. Once TB bacilli have entered the host by the respiratory route and infected macrophages in the lungs, they interfere with phagosomal maturation, antigen presentation, apoptosis and host immune system to establish persistent or latent infection. More...
hsa04660	T cell receptor signaling pathway	19	Activation of T lymphocytes is a key event for an efficient ...... Activation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. Engagement of these receptors through the interaction with a foreign antigen associated with major histocompatibility complex molecules and CD28 counter-receptors B7.1/B7.2, respectively, results in a series of signaling cascades. These cascades comprise an array of protein-tyrosine kinases, phosphatases, GTP-binding proteins and adaptor proteins that regulate generic and specialised functions, leading to T-cell proliferation, cytokine production and differentiation into effector cells. More...

Genes shared at least 5 GO terms with MALT1 (count: 118)

Gene Symbol	Pathway Count	Pathway List
TNFAIP3	12	cytoplasm; cytosol; proteolysis; response to molecule of bacterial origin; ubiquitin-protein ligase activity; protein binding; nucleus; innate immune response; protein self-association; negative regulation of apoptotic process; protein oligomerization; protease binding;
CBL	9	cytoplasm; cytosol; plasma membrane; ubiquitin-protein ligase activity; signal transducer activity; protein binding; nucleus; protein ubiquitination; negative regulation of apoptotic process;
PYCARD	9	cytoplasm; cytosol; proteolysis; cysteine-type endopeptidase activity; protein binding; nucleus; innate immune response; positive regulation of T cell activation; positive regulation of NF-kappaB transcription factor activity;
RELA	9	cytoplasm; cytosol; protein binding; nucleus; positive regulation of I-kappaB kinase/NF-kappaB cascade; innate immune response; T cell receptor signaling pathway; negative regulation of apoptotic process; positive regulation of NF-kappaB transcription factor activity;
TRIM32	9	cytoplasm; ubiquitin-protein ligase activity; protein binding; nucleus; innate immune response; protein self-association; protein ubiquitination; negative regulation of apoptotic process; positive regulation of NF-kappaB transcription factor activity;
UBC	9	cytosol; plasma membrane; protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade; innate immune response; T cell receptor signaling pathway; regulation of apoptotic process; positive regulation of NF-kappaB transcription factor activity; protease binding;
GSK3B	8	cytoplasm; cytosol; plasma membrane; protein binding; nucleus; nucleolus; perinuclear region of cytoplasm; negative regulation of apoptotic process;
KLHL20	8	cytoplasm; ubiquitin-protein ligase activity; protein binding; nucleus; nucleolus; perinuclear region of cytoplasm; protein ubiquitination; negative regulation of apoptotic process;
MAPK1	8	cytoplasm; cytosol; protein binding; nucleus; nucleolus; protein complex; innate immune response; T cell receptor signaling pathway;
PRKD1	8	cytoplasm; cytosol; plasma membrane; protein binding; nucleus; positive regulation of I-kappaB kinase/NF-kappaB cascade; innate immune response; positive regulation of NF-kappaB transcription factor activity;
TRIM5	8	cytoplasm; ubiquitin-protein ligase activity; protein binding; nucleus; nucleolus; positive regulation of I-kappaB kinase/NF-kappaB cascade; innate immune response; positive regulation of NF-kappaB transcription factor activity;
UBB	8	cytosol; plasma membrane; protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade; innate immune response; T cell receptor signaling pathway; regulation of apoptotic process; positive regulation of NF-kappaB transcription factor activity;
AIP	7	cytoplasm; cytosol; plasma membrane; signal transducer activity; protein binding; nucleus; nucleolus;
ARRB2	7	cytoplasm; cytosol; plasma membrane; protein binding; nucleus; protein ubiquitination; positive regulation of protein ubiquitination;
BCAR1	7	cytoplasm; cytosol; plasma membrane; signal transducer activity; protein binding; T cell receptor signaling pathway; regulation of apoptotic process;
HERC5	7	cytoplasm; cytosol; ubiquitin-protein ligase activity; protein binding; nucleus; innate immune response; perinuclear region of cytoplasm;
PARK2	7	cytoplasm; cytosol; ubiquitin-protein ligase activity; protein binding; nucleus; positive regulation of I-kappaB kinase/NF-kappaB cascade; perinuclear region of cytoplasm;
PIK3CG	7	cytoplasm; cytosol; plasma membrane; protein binding; innate immune response; T cell proliferation; negative regulation of apoptotic process;
PRKCB	7	cytoplasm; cytosol; plasma membrane; protein binding; nucleus; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB transcription factor activity;
RCHY1	7	cytoplasm; ubiquitin-protein ligase activity; protein binding; nucleus; nucleolus; protein ubiquitination; positive regulation of protein ubiquitination;
SNCA	7	cytoplasm; cytosol; plasma membrane; protein binding; nucleus; perinuclear region of cytoplasm; negative regulation of apoptotic process;
TLR4	7	cytoplasm; plasma membrane; protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade; innate immune response; perinuclear region of cytoplasm; positive regulation of NF-kappaB transcription factor activity;
WWP1	7	cytoplasm; cytosol; plasma membrane; ubiquitin-protein ligase activity; protein binding; nucleus; protein ubiquitination;
ADAM8	6	cytoplasm; plasma membrane; proteolysis; protein binding; protein self-association; positive regulation of NF-kappaB transcription factor activity;
APC	6	cytoplasm; cytosol; plasma membrane; protein binding; nucleus; negative regulation of apoptotic process;
ARRB1	6	cytoplasm; cytosol; plasma membrane; protein binding; nucleus; protein ubiquitination;
ATXN1	6	cytoplasm; protein binding; nucleus; nucleolus; protein self-association; nuclear export;
BAIAP2	6	cytoplasm; cytosol; plasma membrane; protein binding; nucleus; nucleolus;
BARD1	6	cytoplasm; ubiquitin-protein ligase activity; protein binding; nucleus; protein ubiquitination; negative regulation of apoptotic process;
BIRC3	6	cytoplasm; ubiquitin-protein ligase activity; protein binding; nucleus; positive regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of apoptotic process;
BLMH	6	cytoplasm; cytosol; proteolysis; cysteine-type endopeptidase activity; protein binding; nucleus;
CORO1A	6	cytoplasm; plasma membrane; protein binding; nucleus; protein complex; innate immune response;
CRYAB	6	cytoplasm; cytosol; plasma membrane; protein binding; nucleus; negative regulation of apoptotic process;
ID2	6	cytoplasm; cytosol; protein binding; nucleus; nucleolus; protein complex;
ILK	6	cytoplasm; cytosol; plasma membrane; signal transducer activity; protein binding; protein complex;
MAGI2	6	cytoplasm; plasma membrane; signal transducer activity; protein binding; nucleus; perinuclear region of cytoplasm;
MEN1	6	cytoplasm; cytosol; protein binding; nucleus; nucleolus; protein complex;
NCK1	6	cytoplasm; cytosol; plasma membrane; protein binding; nucleus; T cell receptor signaling pathway;
NEDD4L	6	cytoplasm; cytosol; ubiquitin-protein ligase activity; protein binding; nucleus; protein ubiquitination;
NF2	6	cytoplasm; plasma membrane; protein binding; nucleus; nucleolus; perinuclear region of cytoplasm;
PAFAH1B1	6	cytoplasm; cytosol; protein binding; nucleus; nucleolus; perinuclear region of cytoplasm;
PAK1	6	cytoplasm; cytosol; plasma membrane; protein binding; protein complex; T cell receptor signaling pathway;
PDE2A	6	cytoplasm; cytosol; plasma membrane; protein binding; nucleus; perinuclear region of cytoplasm;
PSMC3	6	cytoplasm; cytosol; protein binding; nucleus; perinuclear region of cytoplasm; regulation of apoptotic process;
RFWD2	6	cytoplasm; cytosol; protein binding; nucleus; nucleolus; protein ubiquitination;
RNF31	6	cytoplasm; ubiquitin-protein ligase activity; protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade; T cell receptor signaling pathway; positive regulation of NF-kappaB transcription factor activity;
RNF40	6	cytoplasm; plasma membrane; ubiquitin-protein ligase activity; protein binding; nucleus; nucleolus;
STXBP3	6	cytoplasm; cytosol; plasma membrane; protein binding; nucleus; nucleolus;
UBE3A	6	cytoplasm; cytosol; proteolysis; ubiquitin-protein ligase activity; protein binding; nucleus;
BIRC2	6	cytosol; ubiquitin-protein ligase activity; protein binding; nucleus; positive regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of apoptotic process;
CASP1	6	cytosol; proteolysis; cysteine-type endopeptidase activity; protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade; innate immune response;
PYDC1	6	cytosol; proteolysis; cysteine-type endopeptidase activity; protein binding; nucleus; innate immune response;
AATF	5	cytoplasm; protein binding; nucleus; nucleolus; negative regulation of apoptotic process;
ALKBH8	5	cytoplasm; cytosol; protein binding; nucleus; nucleolus;
ATXN2	5	cytoplasm; protein binding; nucleus; nucleolus; perinuclear region of cytoplasm;
CDCA5	5	cytoplasm; plasma membrane; protein binding; nucleus; nucleolus;
CEP164	5	cytoplasm; cytosol; protein binding; nucleus; nucleolus;
CEP57	5	cytoplasm; cytosol; protein binding; nucleus; nucleolus;
CHD1L	5	cytoplasm; plasma membrane; protein binding; nucleus; nucleolus;
COG3	5	cytoplasm; plasma membrane; protein binding; nucleus; nucleolus;
CRBN	5	cytoplasm; protein binding; nucleus; nucleolus; protein ubiquitination;
CTNND1	5	cytoplasm; cytosol; plasma membrane; protein binding; nucleus;
DAXX	5	cytoplasm; cytosol; protein binding; nucleus; nucleolus;
DCPS	5	cytoplasm; cytosol; protein binding; nucleus; nucleolus;
DPP3	5	cytoplasm; plasma membrane; proteolysis; nucleus; nucleolus;
EHD3	5	cytoplasm; plasma membrane; protein binding; nucleus; perinuclear region of cytoplasm;
FBXO4	5	cytoplasm; ubiquitin-protein ligase activity; protein binding; protein ubiquitination; positive regulation of protein ubiquitination;
FBXO7	5	cytoplasm; ubiquitin-protein ligase activity; protein binding; nucleus; protein complex;
FBXW2	5	cytoplasm; proteolysis; ubiquitin-protein ligase activity; protein binding; protein ubiquitination;
FLT4	5	cytoplasm; plasma membrane; protein binding; nucleus; negative regulation of apoptotic process;
GSTP1	5	cytoplasm; cytosol; protein binding; nucleus; negative regulation of apoptotic process;
HERC2	5	cytoplasm; ubiquitin-protein ligase activity; protein binding; nucleus; protein ubiquitination;
IARS	5	cytoplasm; cytosol; protein binding; nucleus; nucleolus;
IRF7	5	cytoplasm; cytosol; protein binding; nucleus; innate immune response;
KLHL7	5	cytoplasm; plasma membrane; nucleus; nucleolus; protein ubiquitination;
KRT18	5	cytoplasm; protein binding; nucleolus; perinuclear region of cytoplasm; negative regulation of apoptotic process;
LPXN	5	cytoplasm; plasma membrane; protein binding; nucleus; perinuclear region of cytoplasm;
NCF2	5	cytoplasm; cytosol; protein binding; nucleolus; innate immune response;
NEK6	5	cytoplasm; signal transducer activity; protein binding; nucleus; positive regulation of I-kappaB kinase/NF-kappaB cascade;
NUMA1	5	cytoplasm; cytosol; protein binding; nucleus; nucleolus;
PDCD4	5	cytoplasm; cytosol; protein binding; nucleus; nucleolus;
PPP1CA	5	cytoplasm; cytosol; protein binding; nucleus; nucleolus;
PRC1	5	cytoplasm; plasma membrane; protein binding; nucleus; nucleolus;
RILPL1	5	cytoplasm; cytosol; plasma membrane; nucleus; nucleolus;
RPS6KA4	5	cytoplasm; protein binding; nucleus; nucleolus; positive regulation of NF-kappaB transcription factor activity;
RRP8	5	cytoplasm; plasma membrane; protein binding; nucleus; nucleolus;
SAP18	5	cytoplasm; plasma membrane; protein binding; nucleus; nucleolus;
SART1	5	cytoplasm; cytosol; protein binding; nucleus; nucleolus;
STAP1	5	cytoplasm; protein binding; nucleus; nucleolus; protein complex;
STRN3	5	cytoplasm; plasma membrane; protein binding; nucleus; protein complex;
TERF2IP	5	cytoplasm; protein binding; nucleus; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB transcription factor activity;
TFAP2A	5	cytoplasm; protein binding; nucleus; nucleolus; negative regulation of apoptotic process;
TJP1	5	cytoplasm; cytosol; plasma membrane; protein binding; nucleus;
TPPP	5	cytoplasm; plasma membrane; protein binding; nucleus; perinuclear region of cytoplasm;
TRAF1	5	cytoplasm; protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of apoptotic process; positive regulation of NF-kappaB transcription factor activity;
TRIM13	5	cytoplasm; ubiquitin-protein ligase activity; signal transducer activity; protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade;
TRIP12	5	cytoplasm; ubiquitin-protein ligase activity; protein binding; nucleus; protein ubiquitination;
WWOX	5	cytoplasm; cytosol; plasma membrane; protein binding; nucleus;
XRCC5	5	cytoplasm; protein binding; nucleus; nucleolus; negative regulation of apoptotic process;
YAP1	5	cytoplasm; cytosol; protein binding; nucleus; negative regulation of apoptotic process;
AKAP7	5	cytosol; plasma membrane; protein binding; nucleus; protein complex;
CUL5	5	cytosol; plasma membrane; protein binding; nucleus; protein ubiquitination;
EEF1D	5	cytosol; signal transducer activity; protein binding; nucleus; positive regulation of I-kappaB kinase/NF-kappaB cascade;
FADD	5	cytosol; protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade; innate immune response; protease binding;
HSPA8	5	cytosol; plasma membrane; protein binding; nucleus; nucleolus;
KAT5	5	cytosol; protein binding; nucleus; nucleolus; perinuclear region of cytoplasm;
MAPK3	5	cytosol; protein binding; nucleus; nucleolus; innate immune response;
MAPK7	5	cytosol; protein binding; nucleus; innate immune response; negative regulation of apoptotic process;
PIK3R1	5	cytosol; plasma membrane; protein binding; T cell receptor signaling pathway; negative regulation of apoptotic process;
PLCG2	5	cytosol; plasma membrane; signal transducer activity; protein binding; T cell receptor signaling pathway;
PLK1	5	cytosol; protein binding; nucleus; protein ubiquitination; negative regulation of apoptotic process;
RIPK3	5	cytosol; plasma membrane; protein binding; innate immune response; positive regulation of NF-kappaB transcription factor activity;
RNF25	5	cytosol; ubiquitin-protein ligase activity; nucleus; protein ubiquitination; positive regulation of NF-kappaB transcription factor activity;
THY1	5	cytosol; plasma membrane; protein binding; T cell receptor signaling pathway; positive regulation of T cell activation;
ACHE	5	plasma membrane; protein binding; nucleus; protein self-association; perinuclear region of cytoplasm;
GJA1	5	plasma membrane; signal transducer activity; protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein oligomerization;
TIRAP	5	plasma membrane; protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade; innate immune response; positive regulation of NF-kappaB transcription factor activity;
SYVN1	5	protein binding; nucleus; nucleolus; protein ubiquitination; negative regulation of apoptotic process;

Genes shared at least 2 KEGG pathways with MALT1 (count: 11)

Gene Symbol	Pathway Count	Pathway List
MAPK1	3	B cell receptor signaling pathway; Tuberculosis; T cell receptor signaling pathway;
MAPK3	3	B cell receptor signaling pathway; Tuberculosis; T cell receptor signaling pathway;
PPP3R2	3	B cell receptor signaling pathway; Tuberculosis; T cell receptor signaling pathway;
RELA	3	B cell receptor signaling pathway; Tuberculosis; T cell receptor signaling pathway;
FCGR2B	2	B cell receptor signaling pathway; Tuberculosis;
GSK3B	2	B cell receptor signaling pathway; T cell receptor signaling pathway;
NFATC4	2	B cell receptor signaling pathway; T cell receptor signaling pathway;
PIK3CG	2	B cell receptor signaling pathway; T cell receptor signaling pathway;
PIK3R1	2	B cell receptor signaling pathway; T cell receptor signaling pathway;
SYK	2	B cell receptor signaling pathway; Tuberculosis;
MAPK9	2	Tuberculosis; T cell receptor signaling pathway;

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Region: chr18:56338618..56421130 View in gBrowse