ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	RNF144B
Previous Symbol	IBRDC2
Symbol Alias	bA528A10.3
Approved Name	ring finger protein 144B
Previous Name	IBR domain containing 2
Location	6p22.3
Position	chr6:18368986-18469105, +
External Links	HGNC: 21578 Entrez Gene: 255488 Ensembl: ENSG00000137393 UCSC: uc003ncs.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by LD-proxy

Gene related studies (count: 0)

Gene related SNPs (count: 4)

Literature-origin SNPs (count: 0)

LD-proxies (count: 4)

rs_ID	Location	Functional Annotation
rs1886353	Chr6:18454163(Fwd)	intron_variant
rs12191033	Chr6:18427127(Fwd)	intron_variant
rs6924327	Chr6:18426143(Fwd)	intron_variant
rs6927583	Chr6:18424430(Fwd)	intron_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 9)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000151	ubiquitin ligase complex	Cellular Component	IC[12853982]	15
GO:0004842	ubiquitin-protein ligase activity	Molecular Function	IDA[12853982]	52
GO:0005515	protein binding	Molecular Function		910
GO:0005737	cytoplasm	Cellular Component		690
GO:0006915	apoptotic process	Biological Process		111
GO:0008270	zinc ion binding	Molecular Function		323
GO:0016021	integral to membrane	Cellular Component		845
GO:0031966	mitochondrial membrane	Cellular Component		12
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Biological Process	IDA[12853982]	16

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with RNF144B (count: 11)

Gene Symbol	Pathway Count	Pathway List
RCHY1	6	ubiquitin ligase complex; ubiquitin-protein ligase activity; protein binding; cytoplasm; zinc ion binding; protein ubiquitination involved in ubiquitin-dependent protein catabolic process;
BARD1	5	ubiquitin ligase complex; ubiquitin-protein ligase activity; protein binding; cytoplasm; zinc ion binding;
BRAP	5	ubiquitin ligase complex; ubiquitin-protein ligase activity; protein binding; cytoplasm; zinc ion binding;
RNF40	5	ubiquitin ligase complex; ubiquitin-protein ligase activity; protein binding; cytoplasm; zinc ion binding;
WWP1	5	ubiquitin ligase complex; ubiquitin-protein ligase activity; protein binding; cytoplasm; protein ubiquitination involved in ubiquitin-dependent protein catabolic process;
BIRC3	5	ubiquitin-protein ligase activity; protein binding; cytoplasm; apoptotic process; zinc ion binding;
HERC2	5	ubiquitin-protein ligase activity; protein binding; cytoplasm; zinc ion binding; protein ubiquitination involved in ubiquitin-dependent protein catabolic process;
PARK2	5	ubiquitin-protein ligase activity; protein binding; cytoplasm; zinc ion binding; protein ubiquitination involved in ubiquitin-dependent protein catabolic process;
RNF130	5	ubiquitin-protein ligase activity; cytoplasm; apoptotic process; zinc ion binding; integral to membrane;
TRIM13	5	ubiquitin-protein ligase activity; protein binding; cytoplasm; zinc ion binding; integral to membrane;
TRIM32	5	ubiquitin-protein ligase activity; protein binding; cytoplasm; zinc ion binding; protein ubiquitination involved in ubiquitin-dependent protein catabolic process;

Genes shared at least 2 KEGG pathways with RNF144B (count: 0)

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Region: chr6:18368986..18469105 View in gBrowse