ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PSMB7
Symbol Alias	Z
Approved Name	proteasome (prosome, macropain) subunit, beta type, 7
Location	9q34.11-q34.12
Position	chr9:127115744-127177723, -
External Links	HGNC: 9544 Entrez Gene: 5695 Ensembl: ENSG00000136930 UCSC: uc004boj.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
9q33	chr9:117700000-130300000	2 (1/1/0)

Gene related GO terms (count: 30)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 30)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	Biological Process		12
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	Biological Process		10
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	Biological Process		12
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	Biological Process		14
GO:0034641	cellular nitrogen compound metabolic process	Biological Process		30
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0042981	regulation of apoptotic process	Biological Process		32
GO:0000502	proteasome complex	Cellular Component	TAS[8811196]	14
GO:0000278	mitotic cell cycle	Biological Process		63
GO:0000216	M/G1 transition of mitotic cell cycle	Biological Process		13
GO:0000209	protein polyubiquitination	Biological Process		23
GO:0000084	S phase of mitotic cell cycle	Biological Process		20
GO:0000082	G1/S transition of mitotic cell cycle	Biological Process		26
GO:0000075	cell cycle checkpoint	Biological Process		21
GO:0019048	virus-host interaction	Biological Process		54
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process		14
GO:0016070	RNA metabolic process	Biological Process		46
GO:0016071	mRNA metabolic process	Biological Process		34
GO:0010467	gene expression	Biological Process		140
GO:0016032	viral reproduction	Biological Process		57
GO:0006915	apoptotic process	Biological Process		111
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	Biological Process		11
GO:0005839	proteasome core complex	Cellular Component		1
GO:0006521	regulation of cellular amino acid metabolic process	Biological Process		9
GO:0005654	nucleoplasm	Cellular Component		183
GO:0005829	cytosol	Cellular Component		447
GO:0004298	threonine-type endopeptidase activity	Molecular Function		3
GO:0005515	protein binding	Molecular Function		910
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	Biological Process		17
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	Biological Process		14

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03050	Proteasome	7	The proteasome is a protein-destroying apparatus involved in...... The proteasome is a protein-destroying apparatus involved in many essential cellular functions, such as regulation of cell cycle, cell differentiation, signal transduction pathways, antigen processing for appropriate immune responses, stress signaling, inflammatory responses, and apoptosis. It is capable of degrading a variety of cellular proteins in a rapid and timely fashion and most substrate proteins are modified by ubiquitin before their degradation by the proteasome. The proteasome is a large protein complex consisting of a proteolytic core called the 20S particle and ancillary factors that regulate its activity in various ways. The most common form is the 26S proteasome containing one 20S core particle and two 19S regulatory particles that enable the proteasome to degrade ubiquitinated proteins by an ATP-dependent mechanism. Another form is the immunoproteasome containing two 11S regulatory particles, PA28 alpha and PA28 beta, which are induced by interferon gamma under the conditions of intensified immune response. Other regulatory particles include PA28 gamma and PA200. Although PA28 gamma also belongs to a family of activators of the 20S proteasome, it is localized within the nucleus and forms a homoheptamer. PA28 gamma has been implicated in the regulation of cell cycle progression and apoptosis. PA200 has been identified as a large nuclear protein that stimulates proteasomal hydrolysis of peptides. More...

Genes shared at least 5 GO terms with PSMB7 (count: 61)

Gene Symbol	Pathway Count	Pathway List
PSMC3	28	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; antigen processing and presentation of exogenous peptide antigen via MHC class I; cellular nitrogen compound metabolic process; small molecule metabolic process; regulation of apoptotic process; proteasome complex; mitotic cell cycle; M/G1 transition of mitotic cell cycle; protein polyubiquitination; S phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; cell cycle checkpoint; virus-host interaction; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; RNA metabolic process; mRNA metabolic process; gene expression; viral reproduction; apoptotic process; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of cellular amino acid metabolic process; nucleoplasm; cytosol; protein binding; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;
PSMD5	27	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; antigen processing and presentation of exogenous peptide antigen via MHC class I; cellular nitrogen compound metabolic process; small molecule metabolic process; regulation of apoptotic process; proteasome complex; mitotic cell cycle; M/G1 transition of mitotic cell cycle; protein polyubiquitination; S phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; cell cycle checkpoint; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; RNA metabolic process; mRNA metabolic process; gene expression; viral reproduction; apoptotic process; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of cellular amino acid metabolic process; nucleoplasm; cytosol; protein binding; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;
PSMD7	27	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; antigen processing and presentation of exogenous peptide antigen via MHC class I; cellular nitrogen compound metabolic process; small molecule metabolic process; regulation of apoptotic process; proteasome complex; mitotic cell cycle; M/G1 transition of mitotic cell cycle; protein polyubiquitination; S phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; cell cycle checkpoint; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; RNA metabolic process; mRNA metabolic process; gene expression; viral reproduction; apoptotic process; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of cellular amino acid metabolic process; nucleoplasm; cytosol; protein binding; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;
PSME1	26	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; antigen processing and presentation of exogenous peptide antigen via MHC class I; cellular nitrogen compound metabolic process; small molecule metabolic process; regulation of apoptotic process; proteasome complex; mitotic cell cycle; M/G1 transition of mitotic cell cycle; protein polyubiquitination; S phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; cell cycle checkpoint; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; RNA metabolic process; mRNA metabolic process; gene expression; viral reproduction; apoptotic process; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of cellular amino acid metabolic process; nucleoplasm; cytosol; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;
PSME2	26	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; antigen processing and presentation of exogenous peptide antigen via MHC class I; cellular nitrogen compound metabolic process; small molecule metabolic process; regulation of apoptotic process; proteasome complex; mitotic cell cycle; M/G1 transition of mitotic cell cycle; protein polyubiquitination; S phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; cell cycle checkpoint; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; RNA metabolic process; mRNA metabolic process; gene expression; viral reproduction; apoptotic process; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of cellular amino acid metabolic process; nucleoplasm; cytosol; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;
PSMA8	23	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; antigen processing and presentation of exogenous peptide antigen via MHC class I; cellular nitrogen compound metabolic process; small molecule metabolic process; regulation of apoptotic process; mitotic cell cycle; M/G1 transition of mitotic cell cycle; protein polyubiquitination; S phase of mitotic cell cycle; cell cycle checkpoint; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; RNA metabolic process; mRNA metabolic process; gene expression; viral reproduction; apoptotic process; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of cellular amino acid metabolic process; cytosol; threonine-type endopeptidase activity; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;
UBB	23	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; antigen processing and presentation of exogenous peptide antigen via MHC class I; regulation of apoptotic process; mitotic cell cycle; M/G1 transition of mitotic cell cycle; protein polyubiquitination; S phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; cell cycle checkpoint; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; RNA metabolic process; mRNA metabolic process; gene expression; viral reproduction; apoptotic process; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; nucleoplasm; cytosol; protein binding; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;
UBC	23	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; antigen processing and presentation of exogenous peptide antigen via MHC class I; regulation of apoptotic process; mitotic cell cycle; M/G1 transition of mitotic cell cycle; protein polyubiquitination; S phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; cell cycle checkpoint; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; RNA metabolic process; mRNA metabolic process; gene expression; viral reproduction; apoptotic process; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; nucleoplasm; cytosol; protein binding; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;
CDC26	9	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; mitotic cell cycle; cell cycle checkpoint; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; nucleoplasm; cytosol; protein binding;
XPO1	9	mitotic cell cycle; virus-host interaction; RNA metabolic process; mRNA metabolic process; gene expression; viral reproduction; nucleoplasm; cytosol; protein binding;
ANAPC4	8	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; mitotic cell cycle; cell cycle checkpoint; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; nucleoplasm; cytosol;
SKP2	8	mitotic cell cycle; protein polyubiquitination; S phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; nucleoplasm; cytosol; protein binding;
PLK1	7	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; nucleoplasm; cytosol; protein binding;
CDC45	7	mitotic cell cycle; M/G1 transition of mitotic cell cycle; S phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; cell cycle checkpoint; nucleoplasm; protein binding;
CDT1	7	mitotic cell cycle; M/G1 transition of mitotic cell cycle; S phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; nucleoplasm; cytosol; protein binding;
NCBP1	7	RNA metabolic process; mRNA metabolic process; gene expression; viral reproduction; nucleoplasm; cytosol; protein binding;
RRM2	6	small molecule metabolic process; mitotic cell cycle; G1/S transition of mitotic cell cycle; nucleoplasm; cytosol; protein binding;
CCND1	6	mitotic cell cycle; S phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; nucleoplasm; cytosol; protein binding;
HSPA8	6	virus-host interaction; RNA metabolic process; mRNA metabolic process; gene expression; cytosol; protein binding;
MAPK3	6	virus-host interaction; gene expression; apoptotic process; nucleoplasm; cytosol; protein binding;
RAN	6	virus-host interaction; gene expression; viral reproduction; nucleoplasm; cytosol; protein binding;
TCEB1	6	virus-host interaction; gene expression; viral reproduction; nucleoplasm; cytosol; protein binding;
RPL13	6	RNA metabolic process; mRNA metabolic process; gene expression; viral reproduction; cytosol; protein binding;
RPL14	6	RNA metabolic process; mRNA metabolic process; gene expression; viral reproduction; cytosol; protein binding;
RPS3	6	RNA metabolic process; mRNA metabolic process; gene expression; viral reproduction; cytosol; protein binding;
RPS9	6	RNA metabolic process; mRNA metabolic process; gene expression; viral reproduction; cytosol; protein binding;
NCF2	5	antigen processing and presentation of exogenous peptide antigen via MHC class I; cytosol; protein binding; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;
SEC61B	5	antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; protein binding; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;
DHFRP1	5	small molecule metabolic process; mitotic cell cycle; G1/S transition of mitotic cell cycle; nucleoplasm; cytosol;
POLA2	5	mitotic cell cycle; M/G1 transition of mitotic cell cycle; S phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; nucleoplasm;
POLE	5	mitotic cell cycle; M/G1 transition of mitotic cell cycle; S phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; nucleoplasm;
SMC1A	5	mitotic cell cycle; cell cycle checkpoint; gene expression; nucleoplasm; protein binding;
CUL5	5	G1/S transition of mitotic cell cycle; virus-host interaction; viral reproduction; cytosol; protein binding;
RFWD2	5	cell cycle checkpoint; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; nucleoplasm; cytosol; protein binding;
BANF1	5	virus-host interaction; viral reproduction; nucleoplasm; cytosol; protein binding;
HMGA1	5	virus-host interaction; viral reproduction; nucleoplasm; cytosol; protein binding;
MAPK1	5	virus-host interaction; apoptotic process; nucleoplasm; cytosol; protein binding;
NEDD4L	5	virus-host interaction; gene expression; nucleoplasm; cytosol; protein binding;
NXF1	5	virus-host interaction; gene expression; nucleoplasm; cytosol; protein binding;
CNOT6	5	RNA metabolic process; mRNA metabolic process; gene expression; cytosol; protein binding;
DCPS	5	RNA metabolic process; mRNA metabolic process; gene expression; cytosol; protein binding;
DDX6	5	RNA metabolic process; mRNA metabolic process; gene expression; cytosol; protein binding;
FAU	5	RNA metabolic process; mRNA metabolic process; gene expression; viral reproduction; cytosol;
LSM4	5	RNA metabolic process; mRNA metabolic process; gene expression; cytosol; protein binding;
PATL1	5	RNA metabolic process; mRNA metabolic process; gene expression; cytosol; protein binding;
RPL12	5	RNA metabolic process; mRNA metabolic process; gene expression; viral reproduction; cytosol;
RPL35	5	RNA metabolic process; mRNA metabolic process; gene expression; viral reproduction; cytosol;
RPL37	5	RNA metabolic process; mRNA metabolic process; gene expression; viral reproduction; cytosol;
RPL37A	5	RNA metabolic process; mRNA metabolic process; gene expression; viral reproduction; cytosol;
RPL38	5	RNA metabolic process; mRNA metabolic process; gene expression; viral reproduction; cytosol;
RPS12	5	RNA metabolic process; mRNA metabolic process; gene expression; viral reproduction; cytosol;
RPS15A	5	RNA metabolic process; mRNA metabolic process; gene expression; viral reproduction; cytosol;
RPS25	5	RNA metabolic process; mRNA metabolic process; gene expression; viral reproduction; cytosol;
RQCD1	5	RNA metabolic process; mRNA metabolic process; gene expression; cytosol; protein binding;
SMG1	5	RNA metabolic process; mRNA metabolic process; gene expression; cytosol; protein binding;
SMG7	5	RNA metabolic process; mRNA metabolic process; gene expression; cytosol; protein binding;
SNRPB	5	RNA metabolic process; gene expression; nucleoplasm; cytosol; protein binding;
SNRPD1	5	RNA metabolic process; gene expression; nucleoplasm; cytosol; protein binding;
SNRPD2	5	RNA metabolic process; gene expression; nucleoplasm; cytosol; protein binding;
SNRPD3	5	RNA metabolic process; gene expression; nucleoplasm; cytosol; protein binding;
SNRPG	5	RNA metabolic process; gene expression; nucleoplasm; cytosol; protein binding;

Genes shared at least 2 KEGG pathways with PSMB7 (count: 0)

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Region: chr9:127115744..127177723 View in gBrowse