Gene Report
Basic Info
| Approved Symbol |
SMG7
|
| Previous Symbol |
C1orf16 |
| Symbol Alias |
KIAA0250, EST1C, SGA56M, SMG-7 |
| Approved Name |
smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans) |
| Previous Name |
chromosome 1 open reading frame 16 |
| Name Alias |
EST1 telomerase component homolog C (S. cerevisiae) |
| Location |
1q25 |
| Position |
chr1:183441351-183567381, + |
| External Links |
HGNC: 16792
Entrez Gene: 9887
Ensembl: ENSG00000116698
UCSC: uc001gqg.2
|
| No. of Studies |
0 (significant: 0; non-significant: 0; trend: 0) |
| Source |
Mapped by significant region |
Gene related studies (count: 0)
Gene related SNPs (count: 0)
Gene related CNVs (count: 0)
Gene related other variant (count: 0)
Gene related regions (count: 1)
Gene related GO terms (count: 12)
Gene related KEGG pathways (count: 1)
| ID |
Name |
No. of Genes in ADHDgene |
Brief Description |
| hsa03015 |
mRNA surveillance pathway |
17 |
The mRNA surveillance pathway is a quality control mechanism......
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
More...
|
Genes shared at least 5 GO terms with SMG7 (count: 39)
| Gene Symbol |
Pathway Count |
Pathway List |
| SMG1 |
9 |
RNA metabolic process;
gene expression;
mRNA export from nucleus;
cytosol;
cytoplasm;
nucleus;
protein binding;
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
mRNA metabolic process;
|
| NCBP1 |
8 |
RNA metabolic process;
gene expression;
mRNA export from nucleus;
cytosol;
nucleus;
protein binding;
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
mRNA metabolic process;
|
| RPS3 |
8 |
RNA metabolic process;
gene expression;
cytosol;
cytoplasm;
nucleus;
protein binding;
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
mRNA metabolic process;
|
| DCPS |
7 |
RNA metabolic process;
gene expression;
cytosol;
cytoplasm;
nucleus;
protein binding;
mRNA metabolic process;
|
| PSMC3 |
7 |
RNA metabolic process;
gene expression;
cytosol;
cytoplasm;
nucleus;
protein binding;
mRNA metabolic process;
|
| RPL14 |
7 |
RNA metabolic process;
gene expression;
cytosol;
cytoplasm;
protein binding;
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
mRNA metabolic process;
|
| RPS9 |
7 |
RNA metabolic process;
gene expression;
cytosol;
cytoplasm;
protein binding;
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
mRNA metabolic process;
|
| CNOT6 |
6 |
RNA metabolic process;
gene expression;
cytosol;
nucleus;
protein binding;
mRNA metabolic process;
|
| HSPA8 |
6 |
RNA metabolic process;
gene expression;
cytosol;
nucleus;
protein binding;
mRNA metabolic process;
|
| RPL13 |
6 |
RNA metabolic process;
gene expression;
cytosol;
protein binding;
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
mRNA metabolic process;
|
| RPL35 |
6 |
RNA metabolic process;
gene expression;
cytosol;
cytoplasm;
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
mRNA metabolic process;
|
| RPS15A |
6 |
RNA metabolic process;
gene expression;
cytosol;
cytoplasm;
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
mRNA metabolic process;
|
| RPS25 |
6 |
RNA metabolic process;
gene expression;
cytosol;
cytoplasm;
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
mRNA metabolic process;
|
| RQCD1 |
6 |
RNA metabolic process;
gene expression;
cytosol;
nucleus;
protein binding;
mRNA metabolic process;
|
| TNKS1BP1 |
6 |
RNA metabolic process;
gene expression;
cytosol;
cytoplasm;
nucleus;
mRNA metabolic process;
|
| XPO1 |
6 |
RNA metabolic process;
gene expression;
cytosol;
cytoplasm;
protein binding;
mRNA metabolic process;
|
| CLNS1A |
5 |
RNA metabolic process;
gene expression;
cytosol;
nucleus;
protein binding;
|
| DDX6 |
5 |
RNA metabolic process;
gene expression;
cytosol;
protein binding;
mRNA metabolic process;
|
| FAU |
5 |
RNA metabolic process;
gene expression;
cytosol;
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
mRNA metabolic process;
|
| LSM4 |
5 |
RNA metabolic process;
gene expression;
cytosol;
protein binding;
mRNA metabolic process;
|
| PATL1 |
5 |
RNA metabolic process;
gene expression;
cytosol;
protein binding;
mRNA metabolic process;
|
| PDCD4 |
5 |
RNA metabolic process;
cytosol;
cytoplasm;
nucleus;
protein binding;
|
| PSMA8 |
5 |
RNA metabolic process;
gene expression;
cytosol;
nucleus;
mRNA metabolic process;
|
| PSMB7 |
5 |
RNA metabolic process;
gene expression;
cytosol;
protein binding;
mRNA metabolic process;
|
| PSMD5 |
5 |
RNA metabolic process;
gene expression;
cytosol;
protein binding;
mRNA metabolic process;
|
| PSMD7 |
5 |
RNA metabolic process;
gene expression;
cytosol;
protein binding;
mRNA metabolic process;
|
| PSME1 |
5 |
RNA metabolic process;
gene expression;
cytosol;
cytoplasm;
mRNA metabolic process;
|
| RPL12 |
5 |
RNA metabolic process;
gene expression;
cytosol;
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
mRNA metabolic process;
|
| RPL37 |
5 |
RNA metabolic process;
gene expression;
cytosol;
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
mRNA metabolic process;
|
| RPL37A |
5 |
RNA metabolic process;
gene expression;
cytosol;
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
mRNA metabolic process;
|
| RPL38 |
5 |
RNA metabolic process;
gene expression;
cytosol;
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
mRNA metabolic process;
|
| RPS12 |
5 |
RNA metabolic process;
gene expression;
cytosol;
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
mRNA metabolic process;
|
| SNRPD1 |
5 |
RNA metabolic process;
gene expression;
cytosol;
nucleus;
protein binding;
|
| UBB |
5 |
RNA metabolic process;
gene expression;
cytosol;
protein binding;
mRNA metabolic process;
|
| UBC |
5 |
RNA metabolic process;
gene expression;
cytosol;
protein binding;
mRNA metabolic process;
|
| IARS |
5 |
gene expression;
cytosol;
cytoplasm;
nucleus;
protein binding;
|
| MEN1 |
5 |
gene expression;
cytosol;
cytoplasm;
nucleus;
protein binding;
|
| NEDD4L |
5 |
gene expression;
cytosol;
cytoplasm;
nucleus;
protein binding;
|
| YAP1 |
5 |
gene expression;
cytosol;
cytoplasm;
nucleus;
protein binding;
|
Genes shared at least 2 KEGG pathways with SMG7 (count: 0)
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