ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PSME2
Symbol Alias	PA28beta
Approved Name	proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
Location	14q11.2
Position	chr14:24612571-24616430, -
External Links	HGNC: 9569 Entrez Gene: 5721 Ensembl: ENSG00000100911 UCSC: uc001wmj.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
14q12	chr14:24600000-33300000	1 (1/0/0)

Gene related GO terms (count: 27)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 27)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process		14
GO:0016071	mRNA metabolic process	Biological Process		34
GO:0016070	RNA metabolic process	Biological Process		46
GO:0016032	viral reproduction	Biological Process		57
GO:0010467	gene expression	Biological Process		140
GO:0008537	proteasome activator complex	Cellular Component		2
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	Biological Process		11
GO:0006915	apoptotic process	Biological Process		111
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	Biological Process		12
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	Biological Process		12
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	Biological Process		10
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0042981	regulation of apoptotic process	Biological Process		32
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	Biological Process		14
GO:0034641	cellular nitrogen compound metabolic process	Biological Process		30
GO:0000084	S phase of mitotic cell cycle	Biological Process		20
GO:0000209	protein polyubiquitination	Biological Process		23
GO:0000075	cell cycle checkpoint	Biological Process		21
GO:0000082	G1/S transition of mitotic cell cycle	Biological Process		26
GO:0005829	cytosol	Cellular Component		447
GO:0006521	regulation of cellular amino acid metabolic process	Biological Process		9
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	Biological Process		14
GO:0005654	nucleoplasm	Cellular Component		183
GO:0000502	proteasome complex	Cellular Component	TAS[8811196]	14
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	Biological Process		17
GO:0000216	M/G1 transition of mitotic cell cycle	Biological Process		13
GO:0000278	mitotic cell cycle	Biological Process		63

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03050	Proteasome	7	The proteasome is a protein-destroying apparatus involved in...... The proteasome is a protein-destroying apparatus involved in many essential cellular functions, such as regulation of cell cycle, cell differentiation, signal transduction pathways, antigen processing for appropriate immune responses, stress signaling, inflammatory responses, and apoptosis. It is capable of degrading a variety of cellular proteins in a rapid and timely fashion and most substrate proteins are modified by ubiquitin before their degradation by the proteasome. The proteasome is a large protein complex consisting of a proteolytic core called the 20S particle and ancillary factors that regulate its activity in various ways. The most common form is the 26S proteasome containing one 20S core particle and two 19S regulatory particles that enable the proteasome to degrade ubiquitinated proteins by an ATP-dependent mechanism. Another form is the immunoproteasome containing two 11S regulatory particles, PA28 alpha and PA28 beta, which are induced by interferon gamma under the conditions of intensified immune response. Other regulatory particles include PA28 gamma and PA200. Although PA28 gamma also belongs to a family of activators of the 20S proteasome, it is localized within the nucleus and forms a homoheptamer. PA28 gamma has been implicated in the regulation of cell cycle progression and apoptosis. PA200 has been identified as a large nuclear protein that stimulates proteasomal hydrolysis of peptides. More...
hsa04612	Antigen processing and presentation	9

Genes shared at least 5 GO terms with PSME2 (count: 34)

Gene Symbol	Pathway Count	Pathway List
PSME1	27	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mRNA metabolic process; RNA metabolic process; viral reproduction; gene expression; proteasome activator complex; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; apoptotic process; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; small molecule metabolic process; regulation of apoptotic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; cellular nitrogen compound metabolic process; S phase of mitotic cell cycle; protein polyubiquitination; cell cycle checkpoint; G1/S transition of mitotic cell cycle; cytosol; regulation of cellular amino acid metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; nucleoplasm; proteasome complex; antigen processing and presentation of peptide antigen via MHC class I; M/G1 transition of mitotic cell cycle; mitotic cell cycle;
PSMB7	26	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mRNA metabolic process; RNA metabolic process; viral reproduction; gene expression; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; apoptotic process; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; small molecule metabolic process; regulation of apoptotic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; cellular nitrogen compound metabolic process; S phase of mitotic cell cycle; protein polyubiquitination; cell cycle checkpoint; G1/S transition of mitotic cell cycle; cytosol; regulation of cellular amino acid metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; nucleoplasm; proteasome complex; antigen processing and presentation of peptide antigen via MHC class I; M/G1 transition of mitotic cell cycle; mitotic cell cycle;
PSMC3	26	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mRNA metabolic process; RNA metabolic process; viral reproduction; gene expression; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; apoptotic process; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; small molecule metabolic process; regulation of apoptotic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; cellular nitrogen compound metabolic process; S phase of mitotic cell cycle; protein polyubiquitination; cell cycle checkpoint; G1/S transition of mitotic cell cycle; cytosol; regulation of cellular amino acid metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; nucleoplasm; proteasome complex; antigen processing and presentation of peptide antigen via MHC class I; M/G1 transition of mitotic cell cycle; mitotic cell cycle;
PSMD5	26	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mRNA metabolic process; RNA metabolic process; viral reproduction; gene expression; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; apoptotic process; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; small molecule metabolic process; regulation of apoptotic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; cellular nitrogen compound metabolic process; S phase of mitotic cell cycle; protein polyubiquitination; cell cycle checkpoint; G1/S transition of mitotic cell cycle; cytosol; regulation of cellular amino acid metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; nucleoplasm; proteasome complex; antigen processing and presentation of peptide antigen via MHC class I; M/G1 transition of mitotic cell cycle; mitotic cell cycle;
PSMD7	26	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mRNA metabolic process; RNA metabolic process; viral reproduction; gene expression; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; apoptotic process; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; small molecule metabolic process; regulation of apoptotic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; cellular nitrogen compound metabolic process; S phase of mitotic cell cycle; protein polyubiquitination; cell cycle checkpoint; G1/S transition of mitotic cell cycle; cytosol; regulation of cellular amino acid metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; nucleoplasm; proteasome complex; antigen processing and presentation of peptide antigen via MHC class I; M/G1 transition of mitotic cell cycle; mitotic cell cycle;
PSMA8	22	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mRNA metabolic process; RNA metabolic process; viral reproduction; gene expression; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; apoptotic process; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; small molecule metabolic process; regulation of apoptotic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; cellular nitrogen compound metabolic process; S phase of mitotic cell cycle; protein polyubiquitination; cell cycle checkpoint; cytosol; regulation of cellular amino acid metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of peptide antigen via MHC class I; M/G1 transition of mitotic cell cycle; mitotic cell cycle;
UBB	22	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mRNA metabolic process; RNA metabolic process; viral reproduction; gene expression; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; apoptotic process; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; regulation of apoptotic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; S phase of mitotic cell cycle; protein polyubiquitination; cell cycle checkpoint; G1/S transition of mitotic cell cycle; cytosol; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; nucleoplasm; antigen processing and presentation of peptide antigen via MHC class I; M/G1 transition of mitotic cell cycle; mitotic cell cycle;
UBC	22	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mRNA metabolic process; RNA metabolic process; viral reproduction; gene expression; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; apoptotic process; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; regulation of apoptotic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; S phase of mitotic cell cycle; protein polyubiquitination; cell cycle checkpoint; G1/S transition of mitotic cell cycle; cytosol; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; nucleoplasm; antigen processing and presentation of peptide antigen via MHC class I; M/G1 transition of mitotic cell cycle; mitotic cell cycle;
ANAPC4	8	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; cell cycle checkpoint; cytosol; nucleoplasm; mitotic cell cycle;
CDC26	8	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; cell cycle checkpoint; cytosol; nucleoplasm; mitotic cell cycle;
SKP2	7	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; S phase of mitotic cell cycle; protein polyubiquitination; G1/S transition of mitotic cell cycle; cytosol; nucleoplasm; mitotic cell cycle;
XPO1	7	mRNA metabolic process; RNA metabolic process; viral reproduction; gene expression; cytosol; nucleoplasm; mitotic cell cycle;
PLK1	6	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; cytosol; nucleoplasm; mitotic cell cycle;
NCBP1	6	mRNA metabolic process; RNA metabolic process; viral reproduction; gene expression; cytosol; nucleoplasm;
CDC45	6	S phase of mitotic cell cycle; cell cycle checkpoint; G1/S transition of mitotic cell cycle; nucleoplasm; M/G1 transition of mitotic cell cycle; mitotic cell cycle;
CDT1	6	S phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; cytosol; nucleoplasm; M/G1 transition of mitotic cell cycle; mitotic cell cycle;
FAU	5	mRNA metabolic process; RNA metabolic process; viral reproduction; gene expression; cytosol;
RPL12	5	mRNA metabolic process; RNA metabolic process; viral reproduction; gene expression; cytosol;
RPL13	5	mRNA metabolic process; RNA metabolic process; viral reproduction; gene expression; cytosol;
RPL14	5	mRNA metabolic process; RNA metabolic process; viral reproduction; gene expression; cytosol;
RPL35	5	mRNA metabolic process; RNA metabolic process; viral reproduction; gene expression; cytosol;
RPL37	5	mRNA metabolic process; RNA metabolic process; viral reproduction; gene expression; cytosol;
RPL37A	5	mRNA metabolic process; RNA metabolic process; viral reproduction; gene expression; cytosol;
RPL38	5	mRNA metabolic process; RNA metabolic process; viral reproduction; gene expression; cytosol;
RPS12	5	mRNA metabolic process; RNA metabolic process; viral reproduction; gene expression; cytosol;
RPS15A	5	mRNA metabolic process; RNA metabolic process; viral reproduction; gene expression; cytosol;
RPS25	5	mRNA metabolic process; RNA metabolic process; viral reproduction; gene expression; cytosol;
RPS3	5	mRNA metabolic process; RNA metabolic process; viral reproduction; gene expression; cytosol;
RPS9	5	mRNA metabolic process; RNA metabolic process; viral reproduction; gene expression; cytosol;
DHFRP1	5	small molecule metabolic process; G1/S transition of mitotic cell cycle; cytosol; nucleoplasm; mitotic cell cycle;
RRM2	5	small molecule metabolic process; G1/S transition of mitotic cell cycle; cytosol; nucleoplasm; mitotic cell cycle;
CCND1	5	S phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; cytosol; nucleoplasm; mitotic cell cycle;
POLA2	5	S phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; nucleoplasm; M/G1 transition of mitotic cell cycle; mitotic cell cycle;
POLE	5	S phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; nucleoplasm; M/G1 transition of mitotic cell cycle; mitotic cell cycle;

Genes shared at least 2 KEGG pathways with PSME2 (count: 1)

Gene Symbol	Pathway Count	Pathway List
PSME1	2	Proteasome; Antigen processing and presentation;

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Region: chr14:24612571..24616430 View in gBrowse