ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CYBA
Symbol Alias	p22-PHOX
Approved Name	cytochrome b-245, alpha polypeptide
Name Alias	flavocytochrome b-558 alpha polypeptide
Location	16q24
Position	chr16:88709697-88717457, -
External Links	HGNC: 2577 Entrez Gene: 1535 UCSC: uc002flb.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
16q23.1-24.3	chr16:74100000-90354753	1 (1/0/0)

Gene related GO terms (count: 42)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 42)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0071480	cellular response to gamma radiation	Biological Process		4
GO:0001938	positive regulation of endothelial cell proliferation	Biological Process		8
GO:0090382	phagosome maturation	Biological Process		10
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	Biological Process		17
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	Biological Process		14
GO:0003106	negative regulation of glomerular filtration by angiotensin	Biological Process		1
GO:0071260	cellular response to mechanical stimulus	Biological Process		14
GO:0071333	cellular response to glucose stimulus	Biological Process		8
GO:0071356	cellular response to tumor necrosis factor	Biological Process		9
GO:0071407	cellular response to organic cyclic compound	Biological Process		4
GO:0055114	oxidation-reduction process	Biological Process	IMP[2243141]	15
GO:0009055	electron carrier activity	Molecular Function	IDA[12042318]; TAS[2243141]	18
GO:0051701	interaction with host	Biological Process		10
GO:0006954	inflammatory response	Biological Process	IMP[2243141]	51
GO:0071230	cellular response to amino acid stimulus	Biological Process		5
GO:0016175	superoxide-generating NADPH oxidase activity	Molecular Function	IMP[1763037]	2
GO:0070555	response to interleukin-1	Biological Process		6
GO:0014895	smooth muscle hypertrophy	Biological Process		1
GO:0046872	metal ion binding	Molecular Function		170
GO:0005739	mitochondrion	Cellular Component		183
GO:0045730	respiratory burst	Biological Process	IMP[2243141]	3
GO:0005515	protein binding	Molecular Function	IPI[11733522]	910
GO:0050665	hydrogen peroxide biosynthetic process	Biological Process		2
GO:0006801	superoxide metabolic process	Biological Process	IMP[2243141]	3
GO:0046982	protein heterodimerization activity	Molecular Function	IPI[12042318]	68
GO:0005794	Golgi apparatus	Cellular Component		157
GO:0043020	NADPH oxidase complex	Cellular Component	IDA[3305576]; IMP[1763037]	3
GO:0030141	secretory granule	Cellular Component	TAS[12005167]	17
GO:0022900	electron transport chain	Biological Process		12
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	Biological Process		14
GO:0045087	innate immune response	Biological Process	IMP[2243141]	54
GO:0030425	dendrite	Cellular Component		46
GO:0043025	neuronal cell body	Cellular Component		51
GO:0030307	positive regulation of cell growth	Biological Process		8
GO:0017004	cytochrome complex assembly	Biological Process	IDA[7938008]	1
GO:0031667	response to nutrient levels	Biological Process		4
GO:0016324	apical plasma membrane	Cellular Component		51
GO:0030670	phagocytic vesicle membrane	Cellular Component		8
GO:0020037	heme binding	Molecular Function		23
GO:0042554	superoxide anion generation	Biological Process	IMP[2243141]	5
GO:0017124	SH3 domain binding	Molecular Function	IPI[7938008]	22
GO:0042493	response to drug	Biological Process		68

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04380	Osteoclast differentiation	25	The osteoclasts, multinucleared cells originating from the h...... The osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways activated by RANK and immune receptors, whose ligands are expressed on the surface of osteoblasts. Signaling from RANK changes gene expression patterns through transcription factors like NFATc1 and characterizes the active osteoclast. More...
hsa04145	Phagosome	32	Phagocytosis is the process of taking in relatively large pa...... Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes. More...
hsa05140	Leishmaniasis	14	Leishmania is an intracellular protozoan parasite of macroph...... Leishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and proliferate intracellularly by deactivating the macrophage. Successful infection of Leishmania is achieved by alteration of signaling events in the host cell, leading to enhanced production of the autoinhibitory molecules like TGF-beta and decreased induction of cytokines such as IL12 for protective immunity. Nitric oxide production is also inhibited. In addition, defective expression of major histocompatibility complex (MHC) genes silences subsequent T cell activation mediated by macrophages, resulting in abnormal immune responses. More...
hsa04670	Leukocyte transendothelial migration	22	Leukocyte migaration from the blood into tissues is vital fo...... Leukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (CAM) and then migrate across the vascular endothelium. A leukocyte adherent to CAMs on the endothelial cells moves forward by leading-edge protrusion and retraction of its tail. In this process, alphaL /beta2 integrin activates through Vav1, RhoA, which subsequently activates the kinase p160ROCK. ROCK activation leads to MLC phosphorylation, resulting in retraction of the actin cytoskeleton. Moreover, Leukocytes activate endothelial cell signals that stimulate endothelial cell retraction during localized dissociation of the endothelial cell junctions. ICAM-1-mediated signals activate an endothelial cell calcium flux and PKC, which are required for ICAM-1 dependent leukocyte migration. VCAM-1 is involved in the opening of the "endothelial passage" through which leukocytes can extravasate. In this regard, VCAM-1 ligation induces NADPH oxidase activation and the production of reactive oxygen species (ROS) in a Rac-mediated manner, with subsequent activation of matrix metallopoteinases and loss of VE-cadherin-mediated adhesion. More...

Genes shared at least 5 GO terms with CYBA (count: 24)

Gene Symbol	Pathway Count	Pathway List
NCF2	13	phagosome maturation; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; electron carrier activity; interaction with host; respiratory burst; protein binding; superoxide metabolic process; NADPH oxidase complex; antigen processing and presentation of exogenous peptide antigen via MHC class I; innate immune response; superoxide anion generation; response to drug;
NOX4	11	cellular response to gamma radiation; cellular response to glucose stimulus; oxidation-reduction process; electron carrier activity; inflammatory response; superoxide-generating NADPH oxidase activity; mitochondrion; NADPH oxidase complex; apical plasma membrane; heme binding; superoxide anion generation;
TXN	9	cellular response to glucose stimulus; oxidation-reduction process; electron carrier activity; mitochondrion; protein binding; electron transport chain; innate immune response; dendrite; neuronal cell body;
PRKD1	6	positive regulation of endothelial cell proliferation; inflammatory response; metal ion binding; protein binding; Golgi apparatus; innate immune response;
RELA	6	cellular response to tumor necrosis factor; inflammatory response; response to interleukin-1; protein binding; innate immune response; response to drug;
SNCA	6	oxidation-reduction process; response to interleukin-1; mitochondrion; protein binding; Golgi apparatus; response to drug;
ATP6V0D2	5	phagosome maturation; interaction with host; protein binding; apical plasma membrane; phagocytic vesicle membrane;
SLC11A1	5	phagosome maturation; interaction with host; inflammatory response; respiratory burst; phagocytic vesicle membrane;
TCIRG1	5	phagosome maturation; interaction with host; mitochondrion; apical plasma membrane; phagocytic vesicle membrane;
PDIA3	5	antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; electron carrier activity; protein binding; antigen processing and presentation of exogenous peptide antigen via MHC class I;
UBB	5	antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; protein binding; antigen processing and presentation of exogenous peptide antigen via MHC class I; innate immune response;
UBC	5	antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; protein binding; antigen processing and presentation of exogenous peptide antigen via MHC class I; innate immune response;
BAD	5	cellular response to mechanical stimulus; mitochondrion; protein binding; protein heterodimerization activity; response to drug;
BNIP3	5	cellular response to mechanical stimulus; mitochondrion; protein binding; protein heterodimerization activity; dendrite;
IL18	5	cellular response to mechanical stimulus; cellular response to tumor necrosis factor; cellular response to organic cyclic compound; inflammatory response; apical plasma membrane;
MAPK3	5	cellular response to mechanical stimulus; mitochondrion; protein binding; Golgi apparatus; innate immune response;
PDE2A	5	cellular response to mechanical stimulus; metal ion binding; protein binding; Golgi apparatus; dendrite;
TH	5	cellular response to glucose stimulus; mitochondrion; protein binding; dendrite; response to nutrient levels;
MAPK9	5	cellular response to tumor necrosis factor; mitochondrion; protein binding; innate immune response; response to drug;
PYCARD	5	cellular response to tumor necrosis factor; inflammatory response; mitochondrion; protein binding; innate immune response;
CYP2E1	5	oxidation-reduction process; electron carrier activity; mitochondrion; heme binding; response to drug;
DUOX1	5	oxidation-reduction process; hydrogen peroxide biosynthetic process; apical plasma membrane; heme binding; superoxide anion generation;
ADORA2A	5	inflammatory response; protein binding; protein heterodimerization activity; neuronal cell body; response to drug;
ADAM17	5	protein binding; positive regulation of cell growth; apical plasma membrane; SH3 domain binding; response to drug;

Genes shared at least 2 KEGG pathways with CYBA (count: 16)

Gene Symbol	Pathway Count	Pathway List
NCF2	4	Osteoclast differentiation; Phagosome; Leishmaniasis; Leukocyte transendothelial migration;
FCGR2A	3	Osteoclast differentiation; Phagosome; Leishmaniasis;
FCGR2C	3	Osteoclast differentiation; Phagosome; Leishmaniasis;
FCGR3A	3	Osteoclast differentiation; Phagosome; Leishmaniasis;
FCGR3B	3	Osteoclast differentiation; Phagosome; Leishmaniasis;
FCGR2B	2	Osteoclast differentiation; Phagosome;
IFNGR1	2	Osteoclast differentiation; Leishmaniasis;
MAPK1	2	Osteoclast differentiation; Leishmaniasis;
MAPK3	2	Osteoclast differentiation; Leishmaniasis;
PIK3CG	2	Osteoclast differentiation; Leukocyte transendothelial migration;
PIK3R1	2	Osteoclast differentiation; Leukocyte transendothelial migration;
PLCG2	2	Osteoclast differentiation; Leukocyte transendothelial migration;
RELA	2	Osteoclast differentiation; Leishmaniasis;
HLA-DRB1	2	Phagosome; Leishmaniasis;
TLR4	2	Phagosome; Leishmaniasis;
PRKCB	2	Leishmaniasis; Leukocyte transendothelial migration;

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Region: chr16:88709697..88717457 View in gBrowse