ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	BNIP3
Symbol Alias	Nip3
Approved Name	BCL2/adenovirus E1B 19kDa interacting protein 3
Previous Name	BCL2/adenovirus E1B 19kD-interacting protein 3
Location	10q26.3
Position	chr10:133781204-133795435, -
External Links	HGNC: 1084 Entrez Gene: 664 Ensembl: ENSG00000176171 UCSC: uc001lkv.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Jarick[2012]_23	chr10:132453545-135284293 (NCBI36 / hg18)	2830749	10q26.3	del

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 41)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 41)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0070301	cellular response to hydrogen peroxide	Biological Process		10
GO:0055093	response to hyperoxia	Biological Process		4
GO:0051607	defense response to virus	Biological Process	IDA[9973195]	15
GO:0051402	neuron apoptotic process	Biological Process		2
GO:0072593	reactive oxygen species metabolic process	Biological Process	IDA[10891486]	7
GO:0071456	cellular response to hypoxia	Biological Process		12
GO:0071279	cellular response to cobalt ion	Biological Process		1
GO:0071260	cellular response to mechanical stimulus	Biological Process	IEP[19593445]	14
GO:0046902	regulation of mitochondrial membrane permeability	Biological Process	IDA[10891486]	3
GO:0045837	negative regulation of membrane potential	Biological Process	IDA[10891486]	1
GO:0043653	mitochondrial fragmentation involved in apoptotic process	Biological Process		1
GO:0043243	positive regulation of protein complex disassembly	Biological Process		1
GO:0051020	GTPase binding	Molecular Function		3
GO:0050873	brown fat cell differentiation	Biological Process		5
GO:0048102	autophagic cell death	Biological Process		2
GO:0046982	protein heterodimerization activity	Molecular Function	IDA[10381623]	68
GO:0031307	integral to mitochondrial outer membrane	Cellular Component	IDA[10891486]	3
GO:0031966	mitochondrial membrane	Cellular Component	IDA[10891486]; IMP[9396766]	12
GO:0019048	virus-host interaction	Biological Process		54
GO:0030425	dendrite	Cellular Component		46
GO:0042803	protein homodimerization activity	Molecular Function	IDA[9396766]	113
GO:0043066	negative regulation of apoptotic process	Biological Process	TAS[7954800]	77
GO:0035694	mitochondrial protein catabolic process	Biological Process		1
GO:0042802	identical protein binding	Molecular Function	IPI[16189514]	70
GO:0006309	apoptotic DNA fragmentation	Biological Process	IDA[10891486]	3
GO:0006338	chromatin remodeling	Biological Process	IDA[10891486]	10
GO:0005739	mitochondrion	Cellular Component	TAS[9973195]	183
GO:0005741	mitochondrial outer membrane	Cellular Component		21
GO:0008219	cell death	Biological Process	IDA[10891486]	33
GO:0010637	negative regulation of mitochondrial fusion	Biological Process		1
GO:0006915	apoptotic process	Biological Process	IDA[18371312]; IPI[7954800]	111
GO:0006917	induction of apoptosis	Biological Process	IDA[9396766]	31
GO:0005515	protein binding	Molecular Function		910
GO:0001666	response to hypoxia	Biological Process		34
GO:0005635	nuclear envelope	Cellular Component	IDA[7954800]	19
GO:0005634	nucleus	Cellular Component		770
GO:0005737	cytoplasm	Cellular Component		690
GO:0005654	nucleoplasm	Cellular Component		183
GO:0090200	positive regulation of release of cytochrome c from mitochondria	Biological Process		5
GO:0090141	positive regulation of mitochondrial fission	Biological Process		1
GO:0097193	intrinsic apoptotic signaling pathway	Biological Process		6

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with BNIP3 (count: 69)

Gene Symbol	Pathway Count	Pathway List
BAD	11	cellular response to hypoxia; cellular response to mechanical stimulus; regulation of mitochondrial membrane permeability; protein heterodimerization activity; mitochondrion; mitochondrial outer membrane; apoptotic process; induction of apoptosis; protein binding; positive regulation of release of cytochrome c from mitochondria; intrinsic apoptotic signaling pathway;
PMAIP1	10	reactive oxygen species metabolic process; cellular response to hypoxia; regulation of mitochondrial membrane permeability; mitochondrion; mitochondrial outer membrane; apoptotic process; induction of apoptosis; protein binding; nucleus; positive regulation of release of cytochrome c from mitochondria;
PYCARD	8	defense response to virus; protein homodimerization activity; mitochondrion; induction of apoptosis; protein binding; nucleus; cytoplasm; positive regulation of release of cytochrome c from mitochondria;
RELA	8	defense response to virus; virus-host interaction; negative regulation of apoptotic process; identical protein binding; protein binding; nucleus; cytoplasm; nucleoplasm;
VEGFA	8	cellular response to hypoxia; protein heterodimerization activity; protein homodimerization activity; negative regulation of apoptotic process; identical protein binding; protein binding; response to hypoxia; cytoplasm;
MAPK1	8	virus-host interaction; mitochondrion; apoptotic process; induction of apoptosis; protein binding; nucleus; cytoplasm; nucleoplasm;
TRIM5	7	defense response to virus; virus-host interaction; protein homodimerization activity; identical protein binding; protein binding; nucleus; cytoplasm;
EGLN3	7	cellular response to hypoxia; apoptotic process; protein binding; response to hypoxia; nucleus; cytoplasm; nucleoplasm;
MAPK3	7	cellular response to mechanical stimulus; virus-host interaction; mitochondrion; apoptotic process; protein binding; nucleus; nucleoplasm;
TPD52L1	7	protein heterodimerization activity; protein homodimerization activity; identical protein binding; apoptotic DNA fragmentation; induction of apoptosis; protein binding; cytoplasm;
DAXX	7	virus-host interaction; protein homodimerization activity; apoptotic process; induction of apoptosis; protein binding; nucleus; cytoplasm;
CRYAB	7	protein homodimerization activity; negative regulation of apoptotic process; mitochondrion; protein binding; response to hypoxia; nucleus; cytoplasm;
MAPK7	6	cellular response to hydrogen peroxide; negative regulation of apoptotic process; apoptotic process; protein binding; nucleus; nucleoplasm;
PRKAA1	6	cellular response to hydrogen peroxide; cellular response to hypoxia; negative regulation of apoptotic process; protein binding; response to hypoxia; nucleus;
FADD	6	defense response to virus; cellular response to mechanical stimulus; virus-host interaction; identical protein binding; apoptotic process; protein binding;
IL12B	6	defense response to virus; protein heterodimerization activity; protein homodimerization activity; identical protein binding; protein binding; cytoplasm;
GATA6	6	cellular response to hypoxia; negative regulation of apoptotic process; apoptotic process; protein binding; nucleus; nucleoplasm;
PDE2A	6	cellular response to mechanical stimulus; dendrite; protein homodimerization activity; protein binding; nucleus; cytoplasm;
ADRB1	6	brown fat cell differentiation; protein heterodimerization activity; apoptotic process; protein binding; nucleus; cytoplasm;
BARD1	6	protein heterodimerization activity; protein homodimerization activity; negative regulation of apoptotic process; protein binding; nucleus; cytoplasm;
NR4A2	6	protein heterodimerization activity; protein binding; response to hypoxia; nucleus; cytoplasm; nucleoplasm;
PSMC3	6	virus-host interaction; apoptotic process; protein binding; nucleus; cytoplasm; nucleoplasm;
PAK1	6	dendrite; identical protein binding; apoptotic process; protein binding; response to hypoxia; cytoplasm;
TH	6	dendrite; mitochondrion; protein binding; response to hypoxia; nucleus; cytoplasm;
SNCA	6	negative regulation of apoptotic process; identical protein binding; mitochondrion; protein binding; nucleus; cytoplasm;
ATXN1	6	identical protein binding; cell death; protein binding; nucleus; cytoplasm; nucleoplasm;
WWOX	6	mitochondrion; apoptotic process; induction of apoptosis; protein binding; nucleus; cytoplasm;
ETS1	5	cellular response to hydrogen peroxide; induction of apoptosis; protein binding; response to hypoxia; nucleus;
MAP3K5	5	cellular response to hydrogen peroxide; virus-host interaction; protein homodimerization activity; identical protein binding; protein binding;
IRF9	5	defense response to virus; protein binding; nucleus; cytoplasm; nucleoplasm;
MAVS	5	defense response to virus; mitochondrial membrane; virus-host interaction; mitochondrial outer membrane; protein binding;
ATM	5	neuron apoptotic process; negative regulation of apoptotic process; protein binding; response to hypoxia; nucleoplasm;
NDUFS3	5	reactive oxygen species metabolic process; mitochondrial membrane; mitochondrion; induction of apoptosis; protein binding;
CASP1	5	cellular response to mechanical stimulus; apoptotic process; induction of apoptosis; protein binding; response to hypoxia;
CYBA	5	cellular response to mechanical stimulus; protein heterodimerization activity; dendrite; mitochondrion; protein binding;
HNF1B	5	protein heterodimerization activity; protein homodimerization activity; negative regulation of apoptotic process; protein binding; nucleus;
SMC1A	5	protein heterodimerization activity; protein binding; nucleus; cytoplasm; nucleoplasm;
SMC3	5	protein heterodimerization activity; protein binding; nucleus; cytoplasm; nucleoplasm;
DDB1	5	virus-host interaction; protein binding; nucleus; cytoplasm; nucleoplasm;
KRT18	5	virus-host interaction; negative regulation of apoptotic process; apoptotic process; protein binding; cytoplasm;
NEDD4L	5	virus-host interaction; protein binding; nucleus; cytoplasm; nucleoplasm;
SMARCB1	5	virus-host interaction; chromatin remodeling; protein binding; nucleus; nucleoplasm;
XPO1	5	virus-host interaction; protein binding; nuclear envelope; cytoplasm; nucleoplasm;
MAP1S	5	dendrite; identical protein binding; apoptotic process; protein binding; nucleus;
MTMR2	5	dendrite; protein homodimerization activity; protein binding; nucleus; cytoplasm;
OPA1	5	dendrite; mitochondrion; mitochondrial outer membrane; apoptotic process; protein binding;
STRN3	5	dendrite; protein binding; nucleus; cytoplasm; nucleoplasm;
MAP3K11	5	protein homodimerization activity; identical protein binding; cell death; protein binding; cytoplasm;
MLL	5	protein homodimerization activity; identical protein binding; apoptotic process; protein binding; nucleus;
PAFAH1B1	5	protein homodimerization activity; protein binding; nuclear envelope; nucleus; cytoplasm;
SQSTM1	5	protein homodimerization activity; identical protein binding; apoptotic process; protein binding; nucleoplasm;
TFAP2A	5	protein homodimerization activity; negative regulation of apoptotic process; protein binding; nucleus; cytoplasm;
ZBTB16	5	protein homodimerization activity; identical protein binding; apoptotic process; protein binding; nucleus;
AATF	5	negative regulation of apoptotic process; apoptotic process; protein binding; nucleus; cytoplasm;
APC	5	negative regulation of apoptotic process; apoptotic process; protein binding; nucleus; cytoplasm;
BIRC3	5	negative regulation of apoptotic process; apoptotic process; protein binding; nucleus; cytoplasm;
GSTP1	5	negative regulation of apoptotic process; mitochondrion; protein binding; nucleus; cytoplasm;
NUP62	5	negative regulation of apoptotic process; cell death; protein binding; nuclear envelope; cytoplasm;
XRCC5	5	negative regulation of apoptotic process; protein binding; nucleus; cytoplasm; nucleoplasm;
YAP1	5	negative regulation of apoptotic process; protein binding; nucleus; cytoplasm; nucleoplasm;
CBX3	5	identical protein binding; chromatin remodeling; protein binding; nuclear envelope; nucleus;
PRKD1	5	identical protein binding; apoptotic process; protein binding; nucleus; cytoplasm;
MEN1	5	chromatin remodeling; protein binding; nucleus; cytoplasm; nucleoplasm;
SMARCD3	5	chromatin remodeling; protein binding; nucleus; cytoplasm; nucleoplasm;
PARK2	5	mitochondrion; cell death; protein binding; nucleus; cytoplasm;
PERP	5	mitochondrion; apoptotic process; induction of apoptosis; nucleus; cytoplasm;
FUS	5	cell death; protein binding; nucleus; cytoplasm; nucleoplasm;
SMNDC1	5	apoptotic process; induction of apoptosis; protein binding; nucleus; cytoplasm;
SART1	5	protein binding; nucleus; cytoplasm; nucleoplasm; intrinsic apoptotic signaling pathway;

Genes shared at least 2 KEGG pathways with BNIP3 (count: 0)

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Region: chr10:133781204..133795435 View in gBrowse