ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PDIA3
Previous Symbol	GRP58
Symbol Alias	P58, ERp61, ERp57, ERp60, GRP57, PI-PLC, HsT17083
Approved Name	protein disulfide isomerase family A, member 3
Previous Name	glucose regulated protein, 58kDa, "protein disulfide isomerase-associated 3"
Location	15q15
Position	chr15:44038590-44065477, +
External Links	HGNC: 4606 Entrez Gene: 2923 Ensembl: ENSG00000167004 UCSC: uc001zsu.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 24)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0016298	lipase activity	Molecular Function		49

GO terms by database search (count: 23)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	Biological Process		17
GO:0004197	cysteine-type endopeptidase activity	Molecular Function	TAS[9399589]	17
GO:0004629	phospholipase C activity	Molecular Function	TAS[3398923]	6
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	Biological Process		14
GO:0003756	protein disulfide isomerase activity	Molecular Function		3
GO:0005788	endoplasmic reticulum lumen	Cellular Component		33
GO:0006457	protein folding	Biological Process		28
GO:0005515	protein binding	Molecular Function	IPI[17055437]	910
GO:0005783	endoplasmic reticulum	Cellular Component	TAS[16130169]	100
GO:0009986	cell surface	Cellular Component	IDA[19995400]	70
GO:0009055	electron carrier activity	Molecular Function		18
GO:0015035	protein disulfide oxidoreductase activity	Molecular Function		6
GO:0006621	protein retention in ER lumen	Biological Process	TAS[9399589]	1
GO:0006606	protein import into nucleus	Biological Process	TAS[7487104]	5
GO:0007165	signal transduction	Biological Process	TAS[3398923]	171
GO:0006662	glycerol ether metabolic process	Biological Process		5
GO:0044267	cellular protein metabolic process	Biological Process		64
GO:0043687	post-translational protein modification	Biological Process		37
GO:0045454	cell redox homeostasis	Biological Process		13
GO:0042470	melanosome	Cellular Component		22
GO:0018279	protein N-linked glycosylation via asparagine	Biological Process		24
GO:0043065	positive regulation of apoptotic process	Biological Process		34
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	Biological Process		14

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04612	Antigen processing and presentation	9
hsa04141	Protein processing in endoplasmic reticulum	26	The endoplasmic reticulum (ER) is a subcellular organelle wh...... The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis. More...

Genes shared at least 5 GO terms with PDIA3 (count: 14)

Gene Symbol	Pathway Count	Pathway List
PDIA6	10	protein disulfide isomerase activity; endoplasmic reticulum lumen; protein folding; protein binding; endoplasmic reticulum; electron carrier activity; protein disulfide oxidoreductase activity; glycerol ether metabolic process; cell redox homeostasis; melanosome;
CANX	9	antigen processing and presentation of peptide antigen via MHC class I; endoplasmic reticulum lumen; protein folding; protein binding; endoplasmic reticulum; cellular protein metabolic process; post-translational protein modification; melanosome; protein N-linked glycosylation via asparagine;
GANAB	6	endoplasmic reticulum lumen; protein folding; cellular protein metabolic process; post-translational protein modification; melanosome; protein N-linked glycosylation via asparagine;
TXN	6	protein binding; electron carrier activity; protein disulfide oxidoreductase activity; signal transduction; glycerol ether metabolic process; cell redox homeostasis;
CYBA	5	antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; protein binding; electron carrier activity; antigen processing and presentation of exogenous peptide antigen via MHC class I;
NCF2	5	antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; protein binding; electron carrier activity; antigen processing and presentation of exogenous peptide antigen via MHC class I;
SEC61B	5	antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; protein binding; cellular protein metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I;
TAPBP	5	antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; protein binding; endoplasmic reticulum; antigen processing and presentation of exogenous peptide antigen via MHC class I;
PYCARD	5	cysteine-type endopeptidase activity; protein binding; endoplasmic reticulum; signal transduction; positive regulation of apoptotic process;
ERP44	5	protein disulfide isomerase activity; endoplasmic reticulum lumen; protein folding; cell surface; cell redox homeostasis;
EDEM2	5	endoplasmic reticulum lumen; protein folding; cellular protein metabolic process; post-translational protein modification; protein N-linked glycosylation via asparagine;
EDEM3	5	endoplasmic reticulum lumen; protein folding; cellular protein metabolic process; post-translational protein modification; protein N-linked glycosylation via asparagine;
HSPA5	5	endoplasmic reticulum lumen; protein binding; endoplasmic reticulum; cell surface; melanosome;
LMAN1	5	protein folding; protein binding; cellular protein metabolic process; post-translational protein modification; protein N-linked glycosylation via asparagine;

Genes shared at least 2 KEGG pathways with PDIA3 (count: 4)

Gene Symbol	Pathway Count	Pathway List
CANX	2	Antigen processing and presentation; Protein processing in endoplasmic reticulum;
HSPA5	2	Antigen processing and presentation; Protein processing in endoplasmic reticulum;
HSPA6	2	Antigen processing and presentation; Protein processing in endoplasmic reticulum;
HSPA8	2	Antigen processing and presentation; Protein processing in endoplasmic reticulum;

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Region: chr15:44038590..44065477 View in gBrowse