ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	SMPD2
Symbol Alias	nSMase, ISC1
Approved Name	sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
Location	6q21
Position	chr6:109761931-109765122, +
External Links	HGNC: 11121 Entrez Gene: 6610 Ensembl: ENSG00000135587 UCSC: uc003pti.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 15)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0016298	lipase activity	Molecular Function		49

GO terms by database search (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0006687	glycosphingolipid metabolic process	Biological Process		9
GO:0006684	sphingomyelin metabolic process	Biological Process	TAS[9520418]	3
GO:0009612	response to mechanical stimulus	Biological Process		9
GO:0007243	intracellular protein kinase cascade	Biological Process		19
GO:0005901	caveola	Cellular Component		12
GO:0005887	integral to plasma membrane	Cellular Component	TAS[9520418]	220
GO:0006665	sphingolipid metabolic process	Biological Process		16
GO:0006644	phospholipid metabolic process	Biological Process		59
GO:0005886	plasma membrane	Cellular Component		772
GO:0004767	sphingomyelin phosphodiesterase activity	Molecular Function		5
GO:0048011	nerve growth factor receptor signaling pathway	Biological Process		42
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0046513	ceramide biosynthetic process	Biological Process		3
GO:0046872	metal ion binding	Molecular Function		170

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa00600	Sphingolipid metabolism	10
hsa01100	Metabolic pathways	237

Genes shared at least 5 GO terms with SMPD2 (count: 8)

Gene Symbol	Pathway Count	Pathway List
ENPP7	8	glycosphingolipid metabolic process; sphingomyelin metabolic process; sphingolipid metabolic process; phospholipid metabolic process; plasma membrane; sphingomyelin phosphodiesterase activity; lipase activity; small molecule metabolic process;
SMPD1	8	glycosphingolipid metabolic process; sphingomyelin metabolic process; sphingolipid metabolic process; phospholipid metabolic process; sphingomyelin phosphodiesterase activity; lipase activity; small molecule metabolic process; ceramide biosynthetic process;
SMPD4	8	glycosphingolipid metabolic process; sphingolipid metabolic process; phospholipid metabolic process; sphingomyelin phosphodiesterase activity; lipase activity; small molecule metabolic process; ceramide biosynthetic process; metal ion binding;
PRKD1	7	intracellular protein kinase cascade; integral to plasma membrane; sphingolipid metabolic process; phospholipid metabolic process; plasma membrane; small molecule metabolic process; metal ion binding;
NEU3	6	glycosphingolipid metabolic process; integral to plasma membrane; sphingolipid metabolic process; phospholipid metabolic process; plasma membrane; small molecule metabolic process;
STS	6	glycosphingolipid metabolic process; sphingolipid metabolic process; phospholipid metabolic process; plasma membrane; small molecule metabolic process; metal ion binding;
ARSJ	5	glycosphingolipid metabolic process; sphingolipid metabolic process; phospholipid metabolic process; small molecule metabolic process; metal ion binding;
SUMF1	5	glycosphingolipid metabolic process; sphingolipid metabolic process; phospholipid metabolic process; small molecule metabolic process; metal ion binding;

Genes shared at least 2 KEGG pathways with SMPD2 (count: 7)

Gene Symbol	Pathway Count	Pathway List
B4GALT6	2	Sphingolipid metabolism; Metabolic pathways;
ENPP7	2	Sphingolipid metabolism; Metabolic pathways;
SMPD1	2	Sphingolipid metabolism; Metabolic pathways;
SMPD4	2	Sphingolipid metabolism; Metabolic pathways;
SPTLC1	2	Sphingolipid metabolism; Metabolic pathways;
SPTLC3	2	Sphingolipid metabolism; Metabolic pathways;
UGCG	2	Sphingolipid metabolism; Metabolic pathways;

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Region: chr6:109761931..109765122 View in gBrowse