ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	HCN1
Previous Symbol	BCNG1
Symbol Alias	BCNG-1, HAC-2
Approved Name	hyperpolarization activated cyclic nucleotide-gated potassium channel 1
Location	5p12
Position	chr5:45259349-45696253, -
External Links	HGNC: 4845 Entrez Gene: 348980 Ensembl: ENSG00000164588 UCSC: uc003jok.2
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Laurin N, 2008(a)	single marker and haplotype analyses yielded little evidence for significant association	Non-significant

Gene related SNPs (count: 81)

Literature-origin SNPs (count: 5)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs11743392	Chr5:45614975(Fwd)	intron_variant	1(0/1/0)
rs2589162	Chr5:45655893(Fwd)	intron_variant	1(0/1/0)
rs994092	Chr5:45335759(Fwd)	intron_variant	1(0/1/0)
rs16902086	Chr5:45285752(Fwd)	intron_variant	1(0/1/0)
rs7722380	Chr5:45678378(Fwd)	intron_variant	1(0/1/0)

LD-proxies (count: 76)

rs_ID	Location	Functional Annotation
rs2580258	Chr5:45586917(Fwd)	intron_variant
rs1483303	Chr5:45572099(Fwd)	intron_variant; upstream_gene_variant
rs2337483	Chr5:45608322(Fwd)	intron_variant
rs4288123	Chr5:45506986(Fwd)	intron_variant
rs2696013	Chr5:45603206(Fwd)	intron_variant
rs7700252	Chr5:45540813(Fwd)	intron_variant
rs6451810	Chr5:45634000(Fwd)	intron_variant
rs6893773	Chr5:45622496(Fwd)	intron_variant
rs1483308	Chr5:45538384(Fwd)	intron_variant
rs1527833	Chr5:45571017(Fwd)	intron_variant; upstream_gene_variant
rs1527831	Chr5:45656923(Fwd)	intron_variant
rs10473389	Chr5:45561801(Fwd)	downstream_gene_variant; intron_variant
rs2580260	Chr5:45638629(Fwd)	intron_variant
rs7717787	Chr5:45466616(Fwd)	intron_variant
rs10043792	Chr5:45537620(Fwd)	intron_variant
rs10073636	Chr5:45537299(Fwd)	intron_variant
rs1351720	Chr5:45561903(Fwd)	downstream_gene_variant; intron_variant
rs2625494	Chr5:45552766(Fwd)	feature_elongation; intron_variant
rs2049656	Chr5:45579692(Fwd)	downstream_gene_variant; intron_variant
rs755048	Chr5:45596358(Fwd)	intron_variant
rs10069510	Chr5:45597039(Fwd)	intron_variant
rs1405918	Chr5:45655070(Fwd)	intron_variant
rs6451812	Chr5:45692308(Fwd)	intron_variant
rs10074312	Chr5:45671667(Fwd)	intron_variant
rs1405917	Chr5:45673778(Fwd)	intron_variant
rs4339358	Chr5:45651562(Fwd)	intron_variant
rs2337954	Chr5:45651869(Fwd)	intron_variant
rs13361609	Chr5:45697462(Fwd)	upstream_gene_variant
rs1405916	Chr5:45673884(Fwd)	intron_variant
rs4437383	Chr5:45679636(Fwd)	intron_variant
rs6451795	Chr5:45341801(Fwd)	intron_variant
rs1852598	Chr5:45602976(Fwd)	intron_variant
rs34835217	Chr5:45346189(Fwd)	intron_variant
rs16902186	Chr5:45611988(Fwd)	intron_variant
rs13354798	Chr5:45457077(Fwd)	intron_variant
rs7719500	Chr5:45577972(Fwd)	downstream_gene_variant; intron_variant
rs7712920	Chr5:45589206(Fwd)	intron_variant
rs9790873	Chr5:45291514(Fwd)	intron_variant
rs10214369	Chr5:45638511(Fwd)	intron_variant
rs6451804	Chr5:45492205(Fwd)	intron_variant
rs12655983	Chr5:45307926(Fwd)	intron_variant
rs16902199	Chr5:45648757(Fwd)	intron_variant
rs1384732	Chr5:45553387(Fwd)	intron_variant; upstream_gene_variant
rs1501358	Chr5:45338216(Fwd)	intron_variant
rs2589181	Chr5:45612033(Fwd)	intron_variant
rs7706140	Chr5:45474814(Fwd)	intron_variant
rs10060015	Chr5:45339243(Fwd)	intron_variant
rs1534392	Chr5:45633357(Fwd)	intron_variant
rs7727890	Chr5:45478771(Fwd)	intron_variant
rs1483307	Chr5:45491939(Fwd)	intron_variant
rs1483312	Chr5:45515084(Fwd)	intron_variant
rs12656485	Chr5:45513620(Fwd)	intron_variant
rs6451806	Chr5:45530161(Fwd)	intron_variant
rs1351719	Chr5:45520485(Fwd)	intron_variant
rs13358718	Chr5:45488655(Fwd)	intron_variant
rs1471683	Chr5:45479425(Fwd)	intron_variant
rs17293295	Chr5:45509575(Fwd)	intron_variant
rs4532370	Chr5:45506818(Fwd)	intron_variant
rs10044408	Chr5:45388789(Fwd)	intron_variant
rs10473384	Chr5:45343810(Fwd)	intron_variant
rs35804423	Chr5:45354799(Fwd)	intron_variant
rs1501361	Chr5:45326773(Fwd)	intron_variant
rs7709262	Chr5:45342044(Fwd)	intron_variant
rs6874127	Chr5:45305615(Fwd)	intron_variant
rs6895055	Chr5:45321408(Fwd)	intron_variant
rs6864928	Chr5:45298611(Fwd)	intron_variant
rs9292918	Chr5:45301035(Fwd)	intron_variant
rs1392973	Chr5:45307233(Fwd)	intron_variant
rs6888352	Chr5:45325915(Fwd)	intron_variant
rs3923055	Chr5:45391923(Fwd)	intron_variant
rs6874677	Chr5:45393552(Fwd)	intron_variant
rs1501362	Chr5:45378207(Fwd)	intron_variant
rs6451798	Chr5:45387854(Fwd)	intron_variant
rs6451796	Chr5:45356634(Fwd)	intron_variant
rs1501357	Chr5:45364875(Fwd)	intron_variant
rs6871092	Chr5:45469153(Fwd)	intron_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 12)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 12)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005249	voltage-gated potassium channel activity	Molecular Function		3
GO:0005272	sodium channel activity	Molecular Function		4
GO:0005267	potassium channel activity	Molecular Function	NAS[9405696]	7
GO:0046549	retinal cone cell development	Biological Process		4
GO:0030424	axon	Cellular Component		35
GO:0030425	dendrite	Cellular Component		46
GO:0030552	cAMP binding	Molecular Function		5
GO:0045176	apical protein localization	Biological Process		4
GO:0005886	plasma membrane	Cellular Component		772
GO:0006813	potassium ion transport	Biological Process	NAS[9405696]	11
GO:0007268	synaptic transmission	Biological Process		96
GO:0016021	integral to membrane	Cellular Component	NAS[9405696]	845

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with HCN1 (count: 3)

Gene Symbol	Pathway Count	Pathway List
KCNK4	5	potassium channel activity; plasma membrane; potassium ion transport; synaptic transmission; integral to membrane;
KCNK7	5	potassium channel activity; plasma membrane; potassium ion transport; synaptic transmission; integral to membrane;
GRM7	5	axon; dendrite; plasma membrane; synaptic transmission; integral to membrane;

Genes shared at least 2 KEGG pathways with HCN1 (count: 0)

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Region: chr5:45259349..45696253 View in gBrowse