ADHDgene Database

Gene Report

Basic Info

Approved Symbol	FECH
Approved Name	ferrochelatase
Previous Name	ferrochelatase (protoporphyria)
Name Alias	protoporphyria
Location	18q21.2-q21.3
Position	chr18:55212073-55254004, -
External Links	HGNC: 3647 Entrez Gene: 2235 Ensembl: ENSG00000066926 UCSC: uc002lgp.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
18q21.31-21.32	chr18:53800000-59000000	1 (1/0/0)

Gene related GO terms (count: 21)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0010999	regulation of eIF2 alpha phosphorylation by heme	Biological Process		1
GO:0020037	heme binding	Molecular Function		23
GO:0009416	response to light stimulus	Biological Process	TAS[1376018]	7
GO:0009589	detection of UV	Biological Process		1
GO:0034379	very-low-density lipoprotein particle assembly	Biological Process		2
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0030218	erythrocyte differentiation	Biological Process		4
GO:0030350	iron-responsive element binding	Molecular Function		2
GO:0051537	2 iron, 2 sulfur cluster binding	Molecular Function		3
GO:0055072	iron ion homeostasis	Biological Process		3
GO:0046501	protoporphyrinogen IX metabolic process	Biological Process	IDA[15123683]	1
GO:0046984	regulation of hemoglobin biosynthetic process	Biological Process		1
GO:0004325	ferrochelatase activity	Molecular Function	IDA[15123683]	1
GO:0005743	mitochondrial inner membrane	Cellular Component		44
GO:0005515	protein binding	Molecular Function	IPI[15123683]	910
GO:0006091	generation of precursor metabolites and energy	Biological Process	TAS[1729699]	7
GO:0005759	mitochondrial matrix	Cellular Component		32
GO:0006783	heme biosynthetic process	Biological Process		3
GO:0006778	porphyrin-containing compound metabolic process	Biological Process		4
GO:0008203	cholesterol metabolic process	Biological Process		16
GO:0008198	ferrous iron binding	Molecular Function	TAS[1729699]	5

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa01100	Metabolic pathways	237
hsa00860	Porphyrin and chlorophyll metabolism	24

Genes shared at least 5 GO terms with FECH (count: 1)

Gene Symbol	Pathway Count	Pathway List
CYP27A1	5	heme binding; small molecule metabolic process; mitochondrial inner membrane; mitochondrial matrix; cholesterol metabolic process;

Genes shared at least 2 KEGG pathways with FECH (count: 22)

Gene Symbol	Pathway Count	Pathway List
ALAD	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
EARS2	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
HMBS	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT1A1	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT1A10	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT1A3	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT1A4	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT1A5	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT1A6	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT1A7	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT1A8	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT1A9	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT2A1	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT2A2	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT2A3	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT2B10	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT2B11	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT2B15	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT2B17	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT2B28	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT2B4	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
UGT2B7	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;

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Region: chr18:55212073..55254004 View in gBrowse