Gene Report
Basic Info
Approved Symbol |
CYP27A1
|
Previous Symbol |
CYP27 |
Symbol Alias |
CTX, CP27 |
Approved Name |
cytochrome P450, family 27, subfamily A, polypeptide 1 |
Previous Name |
cytochrome P450, subfamily XXVIIA (steroid 27-hydroxylase, cerebrotendinous xanthomatosis), polypeptide 1 |
Name Alias |
cerebrotendinous xanthomatosis |
Location |
2q33-qter |
Position |
chr2:219646472-219680016, + |
External Links |
HGNC: 2605
Entrez Gene: 1593
Ensembl: ENSG00000135929
UCSC: uc002viz.3
|
No. of Studies |
0 (significant: 0; non-significant: 0; trend: 0) |
Source |
Mapped by significant region |
Gene related studies (count: 0)
Gene related SNPs (count: 0)
Gene related CNVs (count: 0)
Gene related other variant (count: 0)
Gene related regions (count: 1)
Gene related GO terms (count: 14)
Gene related KEGG pathways (count: 3)
ID |
Name |
No. of Genes in ADHDgene |
Brief Description |
hsa00120 |
Primary bile acid biosynthesis |
4 |
Bile acids are steroid carboxylic acids derived from cholest......
Bile acids are steroid carboxylic acids derived from cholesterol in vertebrates. The primary bile acids, cholic acid and chenodeoxycholic acid, are synthesized in the liver and conjugated with taurine or glycine before secretion via bile into the intestine. The conversion from cholesterol to cholic and chenodeoxycholic acids involves four steps: 1) the initiation of synthesis by 7alpha-hydroxylation of sterol precursors, 2) further modifications to the ring structures, 3) side-chain oxidation and shortening (cleavage) by three carbons, and 4) conjugation of the bile acid with taurine or glycine.
More...
|
hsa01100 |
Metabolic pathways |
237 |
|
hsa03320 |
PPAR signaling pathway |
12 |
Peroxisome proliferator-activated receptors (PPARs) are nucl......
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake.
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|
Genes shared at least 5 GO terms with CYP27A1 (count: 3)
Genes shared at least 2 KEGG pathways with CYP27A1 (count: 3)
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