Study Report
Basic Info
| Reference |
Silva MA, 200920098830
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| Citation |
Silva M. A., Cordeiro Q., Louza M. and Vallada H. (2009) "Association between a SLC6A3 intron 8 VNTR functional polymorphism and ADHD in a Brazilian sample of adult patients." Rev Bras Psiquiatr, 31(4): 390-95.
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| Study Design |
case-control |
| Study Type |
Candidate-gene association study |
| Sample Size |
94 cases and 481 controls |
| Predominant Ethnicity |
Brazilian |
| Population |
Brazil |
| Gender |
58 (61.20%) males and 36 (38.30%) females in case group; 323 (67.15%) males and 158 (32.85%) females in control group |
| Age Group |
Adults
:
mean age 33.0 years (SD=9.21) for case group; mean age 32.5 years (SD=9.5) for control group
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Detail Info
| Summary |
In this study, they performed an investigation of a six-copy 30-bp variable-number tandem repeat (VNTR) functional polymorphism located in SLC6A3 intron 8 in a Brazilian sample comprised by 94 adult patients with DSM-IV ADHD and 481 control subjects. Results shown that the 6-repeat allele was statistically associated with ADHD. The present study provides evidence for the association between the 6-repeat allele of the investigated polymorphism and ADHD in their Brazilian sample of adult patients. |
| Total Sample |
A Brazilian sample comprised by 94 adult patients with DSM-IV ADHD and 481 control subjects was used in this study. |
| Sample Collection |
The study was previously approved by the Clinical Hospital Ethics Committee and all participants gave their written informed consent. |
| Diagnosis Description |
DSM-IV |
| Analysis Method |
The statistical power of the sample was evaluated using the CaTS Program. Polymorphism frequency differences were investigated by the Monte Carlo method using the Clump v1.9 with 10,000 simulations. To perform such analysis, we have collapsed columns with small values into one group to maximize the chi-square value and produce more conservative results. The Hardy-Weinberg equilibrium was tested using the HWE Program. The genotypic distribution was in Hardy-Weinberg equilibrium (cases: X2=1.15, p=0.99 and controls: X2=8.65, p=0.76). The power of the sample, a estimated disorder prevalence in adults of 2.0%, average allelic frequency around 40%, multiplicative model with the genotype relative risk=1.6, and significance level of 0.05, was 86%. |
| Result Description |
The 6-repeat allele was statistically associated with ADHD (X2=6.30, p=0.038). |
Other variant reported by this study (count: 1)
| Variant Name |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result of Statistical Analysis |
| SLC6A3 intron8 VNTR |
4-7, 10 repeat |
6-repeat |
allelic chi-square test P-value=0.038
allelic chi-square test P-value=0.038
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The 6-repeat allele was statistically associated with ADHD |
Significant
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Genes reported by this study (count: 1)
| Gene |
Statistical Values/Author Comments |
Result of Statistical Analysis |
| SLC6A3 |
The present study provides evidence for the association betw......
The present study provides evidence for the association between the 6-repeat allele of SLC6A3 intron 8 VNTR and ADHD in their Brazilian sample of adult patients.
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Significant
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