ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Study Report

Basic Info

Reference	Landaas ET, 201121276201
Citation	Landaas E. T., Johansson S., Halmoy A., Oedegaard K. J., Fasmer O. B. and Haavik J. (2011) "Bipolar disorder risk alleles in adult ADHD patients." Genes Brain Behav, 10(4): 418-23.
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	561 patients and 711 controls
Predominant Ethnicity	Caucasian
Population	Norway
Gender	290 male patients, 285 male controls
Age Group	Adults : case: mean age=34.1 years, SD=10.4, control: mean age=29.6 years, SD=6.5

Detail Info

Summary	They wanted to examine whether the reported BD genetic variants in CACNA1C, ANK3, MYO5B, TSPAN8 and ZNF804A loci are associated with ADHD or with scores on the Mood Disorder Questionnaire (MDQ), a commonly used screening instrument for bipolar spectrum disorders. They studied 561 adult Norwegian ADHD patients and 711 controls from the general population. No significant associations or trends were found between any of the single nucleotide polymorphisms (SNPs) studied and ADHD. However, a weak association was found between rs1344706 in ZNF804A and MDQ.
Total Sample	The sample consists of 1272 Caucasians of Norwegian ancestry, all of more than 18 years of age. Of these, 561 were patients diagnosed with ADHD, 711 were healthy controls.
Sample Collection	The majority of the patients were recruited by responding to an invitation sent by letter to their addresses, as listed in a Norwegian national registry of adult ADHD patients. The control group consisted of 711 volunteers from the general population recruited from all across Norway for the purpose of this study.
Diagnosis Description	Patients were diagnosed with ADHD according to ICD-10 research criteria (World Health Organization 1993), with two modifications: allowing the inattentive subtype in DSM-IV as sufficient for the diagnosis and allowing for the presence of comorbid psychiatric disorders, as long as the criteria for ADHD were present before the appearance of the comorbid disorder (Johansson et al . 2008).
Technique	Samples of either whole blood or saliva were obtained from all participants, and the Oragene DNA Self-Collection Kit (DNA Genotek Inc., Ontario, Canada) was used for DNA extraction. SNP genotyping was performed using the MassARRAY iPLEX System (Sequenom, San Diego, CA, USA).
Analysis Method	The genetic statistical analyses were performed with the PLINK software version 1.07 (Purcell et al . 2007), based on an additive allelic model and using linear/logistic regression with gender and ADHD status as covariates. A two-tailed level of P<0.05 was chosen for nominal significance, and all P-values are presented without correction for multiple testing.
Result Description	No significant associations or trends were found between any of the single nucleotide polymorphisms (SNPs) studied and ADHD [odds ratios (ORs)<=1.05]. However, a weak association was found between rs1344706 in ZNF804A (OR=1.25; P=0.05) and MDQ. In conclusion, it seems unlikely that these six SNPs with strong evidence of association in BD GWA studies are shared risk variants between ADHD and BD.

SNPs reported by this study (count: 6)

SNP	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
rs4939921		C	P-value=0.22, OR=0.85 for frequencies of the BD risk alleles and genotypes in ADHD	did not show any association with ADHD did not show any association with ADHD	Non-significant
rs1705236		A	P-value=0.77, OR=1.05 for frequencies of the BD risk alleles and genotypes in ADHD	did not show any association with ADHD did not show any association with ADHD	Non-significant
rs1006737		A	P-value=1, OR=1 for frequencies of the BD risk alleles and genotypes in ADHD	did not show any association with ADHD did not show any association with ADHD	Non-significant
rs10994336		T	P-value=0.57, OR=0.91 for frequencies of the BD risk alleles and genotypes in ADHD	did not show any association with ADHD did not show any association with ADHD	Non-significant
rs9804190		C	P-value=0.23, OR=0.89 for frequencies of the BD risk alleles and genotypes in ADHD	did not show any association with ADHD did not show any association with ADHD	Non-significant
rs1344706		T	P-value=1, OR=1 for frequencies of the BD risk alleles and genotypes in ADHD	did not show any association with ADHD did not show any association with ADHD	Non-significant

Genes reported by this study (count: 5)

Gene	Statistical Values/Author Comments	Result of Statistical Analysis
ANK3	no SNP showed evidence of association no SNP showed evidence of association	Non-significant
MYO5B	no SNP showed evidence of association no SNP showed evidence of association	Non-significant
ZNF804A	no SNP showed evidence of association no SNP showed evidence of association	Non-significant
CACNA1C	no SNP showed evidence of association no SNP showed evidence of association	Non-significant
TSPAN8	no SNP showed evidence of association no SNP showed evidence of association	Non-significant