Study Report
Basic Info
Reference |
Jiang SD, 200516231731
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Citation |
Jiang S. D., Wu X. D., Zhang Y., Tang G. M., Qian Y. P. and Wang D. X. (2005) "No association between attention-deficit hyperactivity disorder and catechol-O-methyltransferase gene in Chinese." Yi Chuan Xue Bao, 32(8): 784-8.
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Study Design |
family-based |
Study Type |
Candidate-gene association study |
Sample Size |
79 ADHD children and their parents |
Predominant Ethnicity |
Mongoloid |
Population |
China |
Gender |
57 male, 22 female |
Age Group |
Children/Adolescents
:
average age: 11.25 (SD=0.79)
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Detail Info
Summary |
Previous studies suggested that the catecholaminergic systems may be involved in the pathogenesis of attention-deficit hyperactivity disorder (ADHD). Since catechel-o-methyltransferase (COMT) is an enzyme involved in the degradation of catecholaminergic neurotransmitters of the dopaminergic and noradrenergic systems, it is possible that COMT may play a role in ADHD. To test this hypothesis, they used two family-based analyses, the transmission disequilibrium test (TDT) and the haplotype-based haplotype relative risk (HHRR), to examine the possible association between COMT gene and DSM-IV-diagnosed ADHD in a Chinese sample consisting of 79 ADHD probands and their parents. Both TDT and HHRR analyses failed to detect preferential transmission of a COMT allele to the ADHD children. Their data suggested that there was no association between ADHD and COMT gene in the Chinese population. |
Total Sample |
The sample reported in this study consisted of 79 ADHD children and their parents. Among the ADHD children, 57 were male and 22 were female. The average age of these ADHD children was 11.25 years old (SD=0.79). |
Sample Collection |
The sample reported in this study consisted of 79 ADHD children and their parents. |
Diagnosis Description |
The cases met Diagnostic and Statistical Manual of Mental Disorders diagnoses of the combined subtype of ADHD. Each diagnosis was performed separately by at least two different child psychiatrists. |
Technique |
DNA was extracted from peripheral blood cells of these subjects by standard procedure. The G (val158/high activity) and A (Met158/low activity) alleles of the COMT gene were determined by a restriction fragment length polymorphism after PCR amplification and digestion with Nlalll, similar to a published method. |
Analysis Method |
Haplotype-based haplotype relative risk (HHRR) and transmission/disequilibrium test (TDT) analyses were performed to examine the possible association between ADHD and COMT gene. |
Result Description |
Both TDT (X2=1.03, df=1, P>0.05) and HHRR (X2=1.08, df=1, P>0.05) analyses failed to detect preferential transmission of a COMT allele to the ADHD children. Their data suggested that there was no association between ADHD and COMT gene in the Chinese population. |
SNPs reported by this study (count: 1)
SNP |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result of Statistical Analysis |
rs4680 |
G/A |
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allelic TDT P-value>0.05, X2=1.03, df=1; allelic HHRR P-value>0.05, X2=1.08, df=1 |
both TDT and HHRR analyses failed to detect preferential tra......
both TDT and HHRR analyses failed to detect preferential transmission of a COMT allele to the ADHD children
More...
|
Non-significant
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Genes reported by this study (count: 1)
Gene |
Statistical Values/Author Comments |
Result of Statistical Analysis |
COMT |
both TDT and HHRR analyses failed to detect preferential tra......
both TDT and HHRR analyses failed to detect preferential transmission of a COMT allele to the ADHD children; the data suggested that there was no association between ADHD and the COMT gene in the Chinese population
More...
|
Non-significant
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