ADHDgene Database

SNP Report

Basic Info

Name	rs734644 dbSNP Ensembl
Location	Chr4:62800728(Fwd)
Variant Alleles	T/C
Ancestral Allele	C
Functional Annotation	nc_transcript_variant; non_coding_exon_variant; synonymous_variant.
Consequence to Transcript	nc_transcript_variant(ENST00000508078) non_coding_exon_variant(ENST00000508078) synonymous_variant(ENST00000512091; ENST00000514591; ENST00000511324; ENST00000509896; ENST00000506700; ENST00000507164; ENST00000508693; ENST00000514157; ENST00000507625; ENST00000504896; ENST00000508946; ENST00000506746; ENST00000502815; ENST00000506720; ENST00000514996; ENST00000545650)
No. of Studies	1 (significant: 0; non-significant: 0; trend: 1)
Source	Literature-origin

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Domene S, 2011	c.2079T>C		Obs_HET/Pred_HET=0.459/0.427 Obs_HET/Pred_HET=0.459/0.427	neither susceptibility nor protective haplotype alleles are ...... neither susceptibility nor protective haplotype alleles are associated with obviously significant coding region changes, or canonical splice site alterations More...	Trend

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
LPHN3	latrophilin 3	4q13.1	4(3/0/1)

SNPs in LD with rs734644 (count: 12) View in gBrowse (chr4:62761870..62844408 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

rs_ID	Functional Annotation	#studies(significant/non-significant/trend)	r²[population]

rs2305339	intron_variant; nc_transcript_variant; splice_region_variant	2(0/0/2)	1.0[ASW]; 1.0[CEU]; 0.829[CHB]; 0.881[CHD]; 1.0[GIH]; 0.907[JPT]; 0.921[LWK]; 1.0[MEX]; 1.0[MKK]; 1.0[TSI]; 1.0[YRI]

rs_ID	Functional Annotation	r²[population]
rs10030755	intron_variant	0.867[MEX]
rs2122646	intron_variant; upstream_gene_variant	0.954[CEU]
rs1470724	intron_variant	0.854[YRI]
rs17082493	intron_variant; nc_transcript_variant; non_coding_exon_variant	1.0[CEU]
rs1510925	intron_variant	0.829[CHB]; 0.806[CHD]; 0.869[MEX]
rs1355368	intron_variant	0.822[TSI]
rs12503398	intron_variant	0.829[MEX]
rs6843396	downstream_gene_variant; intron_variant	0.854[YRI]
rs10517549	intron_variant	0.86[ASW]; 0.881[GIH]; 0.865[JPT]; 0.874[MEX]; 0.981[MKK]; 0.87[TSI]; 0.951[YRI]
rs10023425	intron_variant	0.832[CEU]
rs1349408	intron_variant	0.854[YRI]