ADHDgene Database

SNP Report

Basic Info

Name	rs6311 dbSNP Ensembl
Location	Chr13:47471478(Fwd)
Variant Alleles	C/T
Ancestral Allele	C
Functional Annotation	upstream_gene_variant.
Consequence to Transcript	upstream_gene_variant(ENST00000542664; ENST00000378688; ENST00000543956)
No. of Studies	4 (significant: 0; non-significant: 4; trend: 0)
Source	Literature-origin

SNP related studies (count: 4)

Reference	Allele Change	Statistical Values	Author Comments	Result of Statistical Analysis
Brookes K, 2006	A/G	UNPHASED TDT P-value=0.183; WHAP TDT P-value=0.321 UNPHASED TDT P-value=0.183; WHAP TDT P-value=0.321	no significant association was observed no significant association was observed	Non-significant
Heiser P, 2007	G/A	allelic PDT P-value=0.40 allelic PDT P-value=0.40	showed no statistically significant preferential transmissio...... showed no statistically significant preferential transmission of any allele More...	Non-significant
Gizer IR, 2009		Meta-analysis model: Fixed: OR=1.04, 95% CI=0.94-1.14, two-t...... Meta-analysis model: Fixed: OR=1.04, 95% CI=0.94-1.14, two-tailed P-value=0.449; Q-statistic: P-value=0.705, I²=0 More...	no evidence to suggest an association between this polymorph...... no evidence to suggest an association between this polymorphisms and ADHD More...	Non-significant
Bobb AJ, 2005		allelic TDT P-value=0.96, OR=1.01 in case-control analysis; ...... allelic TDT P-value=0.96, OR=1.01 in case-control analysis; allelic TDT P-value=0.67, RR=0.91 in family-based analysis More...	non-significant association non-significant association	Non-significant

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
HTR2A	5-hydroxytryptamine (serotonin) receptor 2A	13q14-q21	12(6/6/0)

SNPs in LD with rs6311 (count: 24) View in gBrowse (chr13:47439371..47523624 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

rs_ID	Functional Annotation	#studies(significant/non-significant/trend)	r²[population]

rs6313	intron_variant; synonymous_variant	4(0/4/0)	0.94[ASW]; 1.0[CEU]; 1.0[CHB]; 1.0[CHD]; 0.954[GIH]; 1.0[JPT]; 0.856[LWK]; 1.0[MEX]; 0.978[TSI]; 0.924[YRI]