ADHDgene Database

SNP Report

Basic Info

Name	rs4549394 dbSNP Ensembl
Location	Chr4:129431298(Fwd)
Variant Alleles	C/T
Ancestral Allele	T
Functional Annotation	intron_variant; nc_transcript_variant.
Consequence to Transcript	intron_variant(ENST00000511497) nc_transcript_variant(ENST00000511497)
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Hinney, A., 2011		T	GWAS P-value=3.58E-05, OR=1.52, Replication FBAT P-value=0.4...... GWAS P-value=3.58E-05, OR=1.52, Replication FBAT P-value=0.425, Combination P-value=5.13E-05 More...	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Non-significant

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
PGRMC2	progesterone receptor membrane component 2	4q26	1(0/1/0)

SNPs in LD with rs4549394 (count: 9) View in gBrowse (chr4:129403432..129450392 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

rs_ID	Functional Annotation	r²[population]
rs7695069		1.0[CHB]; 1.0[CHD]; 0.811[GIH]; 1.0[JPT]; 0.929[MEX]; 0.828[TSI]
rs13134269	intron_variant; nc_transcript_variant	1.0[CHB]; 1.0[CHD]; 0.811[GIH]; 1.0[JPT]; 0.929[MEX]; 0.858[TSI]; 0.811[YRI]
rs2133430	intron_variant; nc_transcript_variant	1.0[CHB]; 1.0[JPT]
rs13115307	intron_variant; nc_transcript_variant	0.862[JPT]
rs17013394		1.0[CHB]; 1.0[JPT]
rs6857394	downstream_gene_variant	1.0[CHB]; 1.0[JPT]
rs6856612	downstream_gene_variant	1.0[CHB]; 1.0[JPT]
rs6821381	intron_variant; nc_transcript_variant	1.0[CHB]; 1.0[CHD]; 0.811[GIH]; 1.0[JPT]; 0.865[MEX]; 0.806[MKK]; 0.828[TSI]
rs6856963	downstream_gene_variant	0.887[CHB]; 1.0[JPT]