ADHDgene Database

SNP Report

Basic Info

Name	rs4448731 dbSNP Ensembl
Location	Chr12:72329106(Fwd)
Variant Alleles	T/C
Ancestral Allele	T
Functional Annotation	upstream_gene_variant.
Consequence to Transcript	upstream_gene_variant(ENST00000333850; ENST00000546576)
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Brookes K, 2006	A/G		UNPHASED TDT P-value=0.607; WHAP TDT P-value=0.535 UNPHASED TDT P-value=0.607; WHAP TDT P-value=0.535	no significant association was observed no significant association was observed	Non-significant

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
TPH2	tryptophan hydroxylase 2	12q15	10(7/3/0)

SNPs in LD with rs4448731 (count: 7) View in gBrowse (chr12:72329106..72338628 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

rs_ID	Functional Annotation	#studies(significant/non-significant/trend)	r²[population]

rs11178999	NMD_transcript_variant; intron_variant	1(0/1/0)	0.866[CHB]; 1.0[JPT]
rs4565946	NMD_transcript_variant; intron_variant	2(0/2/0)	0.853[CEU]
rs4570625	upstream_gene_variant	3(1/2/0)	0.869[CHB]; 1.0[JPT]
rs6582071	upstream_gene_variant	1(1/0/0)	0.871[CHB]; 1.0[JPT]

rs_ID	Functional Annotation	r²[population]
rs11179000	NMD_transcript_variant; intron_variant	0.913[JPT]
rs10748185	NMD_transcript_variant; intron_variant	0.961[CEU]; 0.954[CHB]; 1.0[JPT]
rs10748186	NMD_transcript_variant; intron_variant	0.961[CEU]; 0.954[CHB]; 1.0[JPT]