ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

SNP Report

Basic Info

Name	rs2072744 dbSNP Ensembl
Location	ChrX:43599436(Fwd)
Variant Alleles	T/C
Ancestral Allele	T
Functional Annotation	intron_variant; upstream_gene_variant.
Consequence to Transcript	intron_variant(ENST00000542639; ENST00000338702) upstream_gene_variant(ENST00000490604)
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Guan L, 2009			single SNP association analyses: Nominal P-value=0.012, Empi...... single SNP association analyses: Nominal P-value=0.012, Empirical P-value=0.017 for ADHD; Nominal P-value=0.018, Empirical P-value=0.034 for ADHD-I More...	achieve nominal and empirical significance for ADHD and ADHD...... achieve nominal and empirical significance for ADHD and ADHD-I More...	Significant

SNP related genes (count: 1)

Literature-origin genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
MAOA	monoamine oxidase A	Xp11.4-p11.3	20(13/7/0)

Genes from other sources (count: 0)

SNPs in LD with rs2072744 (count: 44) View in gBrowse (chrX:43511454..43608682 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

Literature-origin SNPs (count: 18)

rs_ID	Functional Annotation	#studies(significant/non-significant/trend)	r²[population]

rs4570308	upstream_gene_variant	1(1/0/0)	0.863[CHB]; 0.872[JPT]
rs3027407	3_prime_UTR_variant; downstream_gene_variant	3(2/1/0)	0.933[CHB]; 1.0[JPT]
rs2239448	intron_variant; upstream_gene_variant	3(3/0/0)	0.933[CHB]; 0.877[JPT]
rs12843268	intron_variant; nc_transcript_variant	3(2/1/0)	1.0[CHB]; 1.0[JPT]; 0.943[YRI]
rs979605	intron_variant; upstream_gene_variant	2(0/2/0)	1.0[CHB]; 0.873[JPT]
rs5953210	upstream_gene_variant	1(1/0/0)	0.858[CHB]; 0.869[JPT]
rs6610845	intron_variant; nc_transcript_variant	1(0/1/0)	1.0[CEU]; 1.0[CHB]; 1.0[JPT]
rs6323	downstream_gene_variant; synonymous_variant	3(0/3/0)	1.0[CHB]; 1.0[JPT]
rs3788863	intron_variant; nc_transcript_variant	1(1/0/0)	0.858[CHB]; 0.933[JPT]
rs3027400	downstream_gene_variant; intron_variant	3(3/0/0)	1.0[CHB]; 1.0[JPT]
rs5905702	intron_variant; nc_transcript_variant	1(0/1/0)	0.858[CHB]; 0.869[JPT]
rs2235185	intron_variant	1(1/0/0)	1.0[CHB]; 1.0[JPT]
rs3788862	intron_variant; nc_transcript_variant	1(1/0/0)	0.863[CHB]; 0.872[JPT]
rs1137070	nc_transcript_variant; non_coding_exon_variant; synonymous_variant	4(3/1/0)	0.931[CHB]; 0.873[JPT]
rs5905859	downstream_gene_variant; intron_variant	2(2/0/0)	0.944[CEU]; 1.0[CHB]; 0.933[JPT]; 0.841[YRI]
rs2283724	intron_variant; nc_transcript_variant	1(0/1/0)	0.944[CEU]; 0.858[CHB]; 0.933[JPT]
rs2205718	intron_variant	1(0/1/0)	1.0[CHB]; 1.0[JPT]
rs2235186	downstream_gene_variant; intron_variant	1(1/0/0)	1.0[CHB]; 1.0[JPT]

LD-proxies (count: 26)

rs_ID	Functional Annotation	r²[population]
rs28401570	intron_variant; nc_transcript_variant	1.0[CHB]; 1.0[JPT]
rs6610846	intron_variant; nc_transcript_variant	1.0[CEU]; 1.0[CHB]; 1.0[JPT]; 0.841[YRI]
rs5906938	intron_variant; nc_transcript_variant	0.858[CHB]; 0.933[JPT]
rs3027401	downstream_gene_variant; intron_variant	1.0[CHB]; 1.0[JPT]
rs6520894	intron_variant; nc_transcript_variant	0.858[CHB]; 0.933[JPT]
rs3027397	intron_variant; nc_transcript_variant	0.945[CEU]; 0.863[CHB]; 0.935[JPT]
rs1465108	intron_variant; nc_transcript_variant	0.858[CHB]; 0.933[JPT]
rs3810709	intron_variant; nc_transcript_variant	1.0[CEU]; 1.0[CHB]; 1.0[JPT]; 0.836[YRI]
rs909525	intron_variant; nc_transcript_variant	0.944[CEU]; 0.858[CHB]; 0.933[JPT]
rs5906729	intron_variant; nc_transcript_variant	0.863[CHB]; 0.935[JPT]
rs3027398	intron_variant; nc_transcript_variant	0.944[CEU]; 0.858[CHB]; 0.933[JPT]
rs1465107	intron_variant; nc_transcript_variant	0.863[CHB]; 0.934[JPT]
rs28556796	intron_variant; nc_transcript_variant	1.0[CHB]; 1.0[JPT]
rs4301558	upstream_gene_variant	0.863[CHB]; 0.872[JPT]
rs2072743	intron_variant; upstream_gene_variant	1.0[CEU]; 1.0[CHB]; 1.0[JPT]; 1.0[YRI]
rs1800659	intron_variant; nc_transcript_variant	1.0[CHB]; 1.0[JPT]; 0.943[YRI]
rs3027396	intron_variant; nc_transcript_variant	0.944[CEU]; 0.858[CHB]; 0.931[JPT]
rs5906883	intron_variant; nc_transcript_variant	0.933[JPT]
rs979606	intron_variant; upstream_gene_variant	1.0[CHB]; 0.873[JPT]
rs2283725	intron_variant; nc_transcript_variant	0.944[CEU]; 0.858[CHB]; 0.933[JPT]
rs3027410	downstream_gene_variant	0.931[CHB]; 0.873[JPT]
rs2064070	downstream_gene_variant	0.931[CHB]; 0.873[JPT]
rs5906974	intron_variant; nc_transcript_variant	0.863[CHB]; 0.935[JPT]
rs5906893	intron_variant; nc_transcript_variant	0.857[CHB]; 0.933[JPT]
rs5953385	intron_variant; nc_transcript_variant	0.858[CHB]; 0.933[JPT]
rs5906957	intron_variant; nc_transcript_variant	0.863[CHB]; 0.935[JPT]