ADHDgene Database

SNP Report

Basic Info

Name	rs1487279 dbSNP Ensembl
Location	Chr12:72419306(Fwd)
Variant Alleles	A/T
Ancestral Allele	T
Functional Annotation	intron_variant.
Consequence to Transcript	intron_variant(ENST00000333850)
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Sheehan K, 2005	A/T		allelic TDT P-value=0.17, X²=2.1, OR=1.3; TDT P-v...... allelic TDT P-value=0.17, X²=2.1, OR=1.3; TDT P-value=0.02, X²=5.9, OR=2.1 of paternal origin; TDT P-value=1, X²=0.02, OR=0.96 of maternal origin More...	the trend towards association of allele A in the total sampl...... the trend towards association of allele A in the total sample was stronger for paternal transmissions More...	Significant

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
TPH2	tryptophan hydroxylase 2	12q15	10(7/3/0)

SNPs in LD with rs1487279 (count: 17) View in gBrowse (chr12:72410021..72419306 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

rs_ID	Functional Annotation	#studies(significant/non-significant/trend)	r²[population]

rs10879357	intron_variant	1(0/1/0)	0.908[CHB]; 0.904[JPT]
rs10879358	intron_variant	1(0/1/0)	0.952[CHB]; 1.0[JPT]

rs_ID	Functional Annotation	r²[population]
rs11179052	intron_variant	0.908[CHB]; 0.86[JPT]
rs1386485	intron_variant	0.908[CHB]; 0.905[JPT]
rs4290270	synonymous_variant	0.912[CHB]; 0.954[JPT]
rs11179050	intron_variant	0.816[CHB]; 0.817[JPT]
rs11179059	intron_variant	0.912[CHB]; 0.954[JPT]
rs4488237	intron_variant	0.908[CHB]; 0.95[JPT]
rs1386483	intron_variant	0.908[CHB]; 0.905[JPT]
rs4430554	intron_variant	0.912[CHB]; 0.954[JPT]
rs1386482	intron_variant	0.91[CHB]; 0.909[JPT]
rs11179049	intron_variant	0.829[CHB]; 0.825[JPT]
rs1386487	feature_truncation; intron_variant	0.91[CHB]; 0.905[JPT]
rs2200579	intron_variant	0.912[CHB]
rs4469933	intron_variant	0.912[CHB]; 0.954[JPT]
rs1386486	intron_variant	0.912[CHB]; 0.909[JPT]
rs10879355	intron_variant	0.908[CHB]; 0.905[JPT]