ADHDgene Database

SNP Report

Basic Info

Name	rs11074889 dbSNP Ensembl
Location	Chr16:10633165(Fwd)
Variant Alleles	A/G
Ancestral Allele	A
Functional Annotation	downstream_gene_variant; intron_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000342147) intron_variant(ENST00000359543; ENST00000536829)
No. of Studies	2 (significant: 0; non-significant: 0; trend: 2)
Source	Literature-origin

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Mick E, 2010		A	TDT P-value=6.71E-07 (OR=1.68) TDT P-value=6.71E-07 (OR=1.68)	One of the top 20 associations from genome-wide association ...... One of the top 20 associations from genome-wide association results; annotated by GWAS Catalog More...	Trend
Neale BM, 2010 (a)	A:G		P-value=2.13E-05 P-value=2.13E-05	one of top 50 hits from the Genome-Wide Attention-Deficit/Hy...... one of top 50 hits from the Genome-Wide Attention-Deficit/Hyperactivity Disorder (ADHD) meta-analysis, and annotated by GWAS catalogue More...	Trend

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
EMP2	epithelial membrane protein 2	16p13.2	2(0/0/2)

SNPs in LD with rs11074889 (count: 13) View in gBrowse (chr16:10607834..10633165 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

rs_ID	Functional Annotation	r²[population]
rs6498070	intron_variant	1.0[CHB]; 0.962[CHD]; 0.955[GIH]; 1.0[JPT]
rs4780938	downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	0.903[CHB]; 1.0[JPT]
rs4780929	downstream_gene_variant	0.931[CHB]; 0.927[JPT]
rs10775284	downstream_gene_variant; intron_variant; upstream_gene_variant	0.931[CHB]; 0.839[GIH]; 0.927[JPT]
rs1875928	downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	0.833[CHB]; 0.843[JPT]
rs7184187	downstream_gene_variant; intron_variant	0.821[JPT]
rs1504884	intron_variant	1.0[CHB]; 0.962[CHD]; 0.955[GIH]; 1.0[JPT]
rs6498069	downstream_gene_variant; intron_variant	0.919[CHB]; 1.0[JPT]
rs2279871	intron_variant	0.813[CEU]; 1.0[CHB]; 0.922[CHD]; 1.0[GIH]; 1.0[JPT]; 1.0[MEX]; 0.814[TSI]
rs12996	3_prime_UTR_variant; downstream_gene_variant; nc_transcript_variant; non_coding_exon_variant; upstream_gene_variant	0.931[CHB]; 0.839[GIH]; 0.924[JPT]
rs3087620	3_prime_UTR_variant; downstream_gene_variant; nc_transcript_variant; non_coding_exon_variant; upstream_gene_variant	0.931[CHB]; 0.839[GIH]; 0.927[JPT]
rs6498062	downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	0.869[CHB]; 0.927[JPT]
rs7194566	3_prime_UTR_variant; downstream_gene_variant; upstream_gene_variant	0.931[CHB]; 0.927[JPT]