ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

SNP Report

Basic Info

Name	rs1079727 dbSNP Ensembl
Location	Chr11:113289182(Fwd)
Variant Alleles	T/C
Ancestral Allele	T
Functional Annotation	intron_variant; nc_transcript_variant; upstream_gene_variant.
Consequence to Transcript	intron_variant(ENST00000544518; ENST00000543292; ENST00000538967; ENST00000362072; ENST00000355319; ENST00000542968; ENST00000540600; ENST00000535984; ENST00000346454) nc_transcript_variant(ENST00000535984; ENST00000540600) upstream_gene_variant(ENST00000539420)
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Nyman ES, 2007			Logistic regression for single markers: Males: P-value=0.039...... Logistic regression for single markers: Males: P-value=0.0393, OR=1.89, 95%CI=1.03-3.45 for 22/12vs.11 More...	Association was observed in males. No evidence of associatio...... Association was observed in males. No evidence of association was seen in the complete sample or in females. More...	Significant

SNP related genes (count: 1)

Literature-origin genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
DRD2	dopamine receptor D2	11q22-q23	10(3/7/0)

Genes from other sources (count: 0)

SNPs in LD with rs1079727 (count: 29) View in gBrowse (chr11:113266821..113314363 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

Literature-origin SNPs (count: 3)

rs_ID	Functional Annotation	#studies(significant/non-significant/trend)	r²[population]

rs1124491	downstream_gene_variant; intron_variant; nc_transcript_variant	1(1/0/0)	1.0[CEU]; 0.955[CHB]; 0.858[JPT]
rs1079595	downstream_gene_variant; intron_variant; nc_transcript_variant	1(1/0/0)	1.0[CEU]; 0.955[CHB]; 0.858[JPT]; 1.0[YRI]
rs1800497	downstream_gene_variant; missense_variant	2(2/0/0)	0.955[CHB]; 0.822[CHD]; 0.859[JPT]

LD-proxies (count: 26)

rs_ID	Functional Annotation	r²[population]
rs7350522	intron_variant; nc_transcript_variant	1.0[CEU]; 0.953[JPT]
rs11214599	downstream_gene_variant; upstream_gene_variant	1.0[CEU]
rs2245805	downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	0.83[CHB]; 0.908[CHD]
rs7118900	3_prime_UTR_variant; NMD_transcript_variant; missense_variant	0.911[CHB]; 0.804[CHD]; 0.811[JPT]
rs2471857	intron_variant; nc_transcript_variant; upstream_gene_variant	0.927[CEU]; 0.955[CHB]; 1.0[CHD]; 0.97[GIH]; 1.0[JPT]; 0.907[MEX]; 1.0[TSI]
rs11214601	downstream_gene_variant; upstream_gene_variant	1.0[CEU]; 0.953[CHB]; 0.857[JPT]
rs2242591	downstream_gene_variant; intron_variant; nc_transcript_variant	0.951[CHB]
rs1079594	downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant	1.0[CEU]; 0.908[CHB]; 0.858[JPT]; 1.0[YRI]
rs2283265	downstream_gene_variant; intron_variant; nc_transcript_variant	1.0[CEU]; 1.0[CHB]; 0.953[JPT]; 1.0[YRI]
rs2471854	intron_variant; nc_transcript_variant; upstream_gene_variant	0.927[CEU]; 0.955[CHB]; 1.0[CHD]; 0.97[GIH]; 1.0[JPT]; 0.907[MEX]; 1.0[TSI]
rs6278	3_prime_UTR_variant; downstream_gene_variant; intron_variant; nc_transcript_variant	1.0[CEU]; 0.955[CHB]; 0.824[CHD]; 0.909[GIH]; 0.858[JPT]; 1.0[MEX]; 1.0[TSI]
rs1125393	intron_variant; nc_transcript_variant; upstream_gene_variant	0.927[CEU]; 0.955[CHB]; 1.0[CHD]; 1.0[GIH]; 1.0[JPT]; 0.907[MEX]; 1.0[TSI]
rs2075654	intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[CEU]; 1.0[CHB]; 1.0[JPT]
rs7103679	intron_variant; nc_transcript_variant	1.0[CEU]; 1.0[JPT]
rs2734836	downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[CEU]; 0.955[CHB]; 1.0[JPT]; 0.816[YRI]
rs1125394	intron_variant; nc_transcript_variant; upstream_gene_variant	0.926[CEU]; 0.955[CHB]; 1.0[JPT]
rs1076560	downstream_gene_variant; intron_variant	1.0[ASW]; 1.0[CEU]; 1.0[CHB]; 0.952[CHD]; 0.887[GIH]; 0.953[JPT]; 0.952[MEX]; 1.0[TSI]; 1.0[YRI]
rs1076562	intron_variant; nc_transcript_variant; upstream_gene_variant	0.83[CHB]; 0.908[CHD]
rs1079596	intron_variant; nc_transcript_variant; upstream_gene_variant	0.927[CEU]; 0.955[CHB]; 1.0[JPT]
rs2005313	intron_variant; nc_transcript_variant; upstream_gene_variant	0.826[CHB]
rs4648319	intron_variant; nc_transcript_variant	1.0[CEU]; 0.852[GIH]; 0.907[JPT]; 0.952[MEX]
rs2471851	intron_variant; nc_transcript_variant	0.926[CEU]; 1.0[JPT]
rs2002453	intron_variant; nc_transcript_variant; upstream_gene_variant	0.83[CHB]; 0.908[CHD]
rs11214607	intron_variant; nc_transcript_variant	1.0[CEU]; 0.907[JPT]
rs1079597	intron_variant; nc_transcript_variant; upstream_gene_variant	0.927[CEU]; 1.0[CHB]; 1.0[CHD]; 1.0[GIH]; 1.0[JPT]; 0.907[MEX]; 1.0[TSI]
rs2734842	downstream_gene_variant; intron_variant; nc_transcript_variant	0.8[YRI]