ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	WNT6
Approved Name	wingless-type MMTV integration site family, member 6
Location	2q35
Position	chr2:219724544-219738955, +
External Links	HGNC: 12785 Entrez Gene: 7475 Ensembl: ENSG00000115596 UCSC: uc002vjc.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
2q35	chr2:215300000-221500000	1 (1/0/0)

Gene related GO terms (count: 22)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 22)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0001664	G-protein coupled receptor binding	Molecular Function		8
GO:0001658	branching involved in ureteric bud morphogenesis	Biological Process		8
GO:0005886	plasma membrane	Cellular Component		772
GO:0005615	extracellular space	Cellular Component		126
GO:0005578	proteinaceous extracellular matrix	Cellular Component		47
GO:0005576	extracellular region	Cellular Component		240
GO:0030182	neuron differentiation	Biological Process		9
GO:0010628	positive regulation of gene expression	Biological Process		28
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process		80
GO:0042475	odontogenesis of dentin-containing tooth	Biological Process		8
GO:0009798	axis specification	Biological Process		4
GO:0007267	cell-cell signaling	Biological Process		38
GO:0009986	cell surface	Cellular Component		70
GO:0009952	anterior/posterior pattern specification	Biological Process		26
GO:0071300	cellular response to retinoic acid	Biological Process		7
GO:0070172	positive regulation of tooth mineralization	Biological Process		2
GO:0072080	nephron tubule development	Biological Process		1
GO:0072079	nephron tubule formation	Biological Process		1
GO:0060070	canonical Wnt receptor signaling pathway	Biological Process		13
GO:0048754	branching morphogenesis of a tube	Biological Process		6
GO:0061303	cornea development in camera-type eye	Biological Process	ISS[16258938]	2
GO:0060684	epithelial-mesenchymal cell signaling	Biological Process		1

Gene related KEGG pathways (count: 5)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04340	Hedgehog signaling pathway	8	The Hedgehog (Hh) family of secreted signaling proteins play...... The Hedgehog (Hh) family of secreted signaling proteins plays a crucial role in development of diverse animal phyla, from Drosophila to humans, regulating morphogenesis of a variety of tissues and organs. Hh signaling is also involved in control of stem cell proliferation in adult tissues and aberrant activation of the Hh pathway has been linked to multiple types of human cancer. Members of the Hh family bind to patched (ptc), thus releasing smoothened (smo) to transduce a signal. Transcriptional activation occurs through the GLI family of proteins resulting in activation of target genes. More...
hsa05217	Basal cell carcinoma	8	Cancer of the skin is the most common cancer in Caucasians a...... Cancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare familial syndrome basal cell nevus syndrome (BCNS, or Gorlin syndrome) that predisposes to development of BCC. In addition, there is strong epidemiological and genetic evidence that demonstrates UV exposure as a risk factor of prime importance. The development of basal cell carcinoma is associated with constitutive activation of sonic hedgehog signaling. The mutations in SMOH, PTCH1, and SHH in BCCs result in continuous activation of target genes. At a cellular level, sonic hedgehog signaling promotes cell proliferation. Mutations in TP53 are also found with high frequency (>50%) in sporadic BCC. More...
hsa04310	Wnt signaling pathway	22	Wnt proteins are secreted morphogens that are required for b...... Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin. More...
hsa05200	Pathways in cancer	52
hsa04916	Melanogenesis	15	Cutaneous melanin pigment plays a critical role in camouflag...... Cutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory control by multiple agents. The most important positive regulator of melanogenesis is the MC1 receptor with its ligands melanocortic peptides. MC1R activates the cyclic AMP (cAMP) response-element binding protein (CREB). Increased expression of MITF and its activation by phosphorylation (P) stimulate the transcription of tyrosinase (TYR), tyrosinase-related protein 1 (TYRP1), and dopachrome tautomerase (DCT), which produce melanin. Melanin synthesis takes place within specialized intracellular organelles named melanosomes. Melanin-containing melanosomes then move from the perinuclear region to the dendrite tips and are transferred to keratinocytes by a still not well-characterized mechanism. More...

Genes shared at least 5 GO terms with WNT6 (count: 6)

Gene Symbol	Pathway Count	Pathway List
WNT11	11	G-protein coupled receptor binding; plasma membrane; extracellular space; proteinaceous extracellular matrix; neuron differentiation; positive regulation of gene expression; positive regulation of transcription, DNA-dependent; axis specification; anterior/posterior pattern specification; cellular response to retinoic acid; canonical Wnt receptor signaling pathway;
WNT10A	8	G-protein coupled receptor binding; plasma membrane; extracellular space; proteinaceous extracellular matrix; positive regulation of gene expression; axis specification; anterior/posterior pattern specification; canonical Wnt receptor signaling pathway;
FGF10	7	plasma membrane; extracellular space; extracellular region; positive regulation of transcription, DNA-dependent; odontogenesis of dentin-containing tooth; cell surface; branching morphogenesis of a tube;
FZD4	6	plasma membrane; neuron differentiation; positive regulation of transcription, DNA-dependent; cell surface; cellular response to retinoic acid; canonical Wnt receptor signaling pathway;
VEGFA	6	extracellular space; proteinaceous extracellular matrix; extracellular region; positive regulation of gene expression; cell surface; branching morphogenesis of a tube;
CTGF	5	plasma membrane; extracellular space; proteinaceous extracellular matrix; extracellular region; positive regulation of gene expression;

Genes shared at least 2 KEGG pathways with WNT6 (count: 16)

Gene Symbol	Pathway Count	Pathway List
GSK3B	5	Hedgehog signaling pathway; Basal cell carcinoma; Wnt signaling pathway; Pathways in cancer; Melanogenesis;
WNT10A	5	Hedgehog signaling pathway; Basal cell carcinoma; Wnt signaling pathway; Pathways in cancer; Melanogenesis;
WNT11	5	Hedgehog signaling pathway; Basal cell carcinoma; Wnt signaling pathway; Pathways in cancer; Melanogenesis;
FZD4	4	Basal cell carcinoma; Wnt signaling pathway; Pathways in cancer; Melanogenesis;
PTCH1	3	Hedgehog signaling pathway; Basal cell carcinoma; Pathways in cancer;
STK36	3	Hedgehog signaling pathway; Basal cell carcinoma; Pathways in cancer;
APC	3	Basal cell carcinoma; Wnt signaling pathway; Pathways in cancer;
PRKCB	3	Wnt signaling pathway; Pathways in cancer; Melanogenesis;
CSNK1E	2	Hedgehog signaling pathway; Wnt signaling pathway;
CAMK2D	2	Wnt signaling pathway; Melanogenesis;
CCND1	2	Wnt signaling pathway; Pathways in cancer;
MAPK9	2	Wnt signaling pathway; Pathways in cancer;
PLCB2	2	Wnt signaling pathway; Melanogenesis;
PLCB3	2	Wnt signaling pathway; Melanogenesis;
MAPK1	2	Pathways in cancer; Melanogenesis;
MAPK3	2	Pathways in cancer; Melanogenesis;

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Region: chr2:219724544..219738955 View in gBrowse