ADHDgene Database

Gene Report

Basic Info

Approved Symbol	TNFSF15
Symbol Alias	TL1, VEGI, TL1A, VEGI192A, MGC129934, MGC129935
Approved Name	tumor necrosis factor (ligand) superfamily, member 15
Name Alias	vascular endothelial cell growth inhibitor, "TNF superfamily ligand TL1A", "TNF ligand-related molecule 1", "vascular endothelial growth inhibitor-192A"
Location	9q32
Position	chr9:117551600-117568408, -
External Links	HGNC: 11931 Entrez Gene: 9966 Ensembl: ENSG00000181634 UCSC: uc004bjh.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
9q31.1-33.1	chr9:102600000-122500000	1 (1/0/0)

Gene related GO terms (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0042107	cytokine metabolic process	Biological Process	IDA[11911831]	1
GO:0016021	integral to membrane	Cellular Component	NAS[9872942]	845
GO:0050715	positive regulation of cytokine secretion	Biological Process		8
GO:0006955	immune response	Biological Process		45
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	Biological Process	IDA[11911831]	11
GO:0007250	activation of NF-kappaB-inducing kinase activity	Biological Process	IDA[11911831]	3
GO:0007165	signal transduction	Biological Process	NAS[9872942]	171
GO:0005164	tumor necrosis factor receptor binding	Molecular Function		5
GO:0005615	extracellular space	Cellular Component		126
GO:0005886	plasma membrane	Cellular Component	IDA[11911831]	772
GO:0005887	integral to plasma membrane	Cellular Component	TAS[9872942]	220
GO:0005102	receptor binding	Molecular Function	TAS[9434163]	61
GO:0005123	death receptor binding	Molecular Function		3
GO:0005125	cytokine activity	Molecular Function		19

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04060	Cytokine-cytokine receptor interaction	38	Cytokines are soluble extracellular proteins or glycoprotein...... Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped. More...

Genes shared at least 5 GO terms with TNFSF15 (count: 5)

Gene Symbol	Pathway Count	Pathway List
TNFSF18	7	integral to membrane; signal transduction; tumor necrosis factor receptor binding; extracellular space; plasma membrane; receptor binding; cytokine activity;
TNFSF8	7	immune response; signal transduction; tumor necrosis factor receptor binding; extracellular space; integral to plasma membrane; receptor binding; cytokine activity;
TNFSF4	6	signal transduction; tumor necrosis factor receptor binding; extracellular space; integral to plasma membrane; receptor binding; cytokine activity;
SEMA4D	5	immune response; extracellular space; plasma membrane; integral to plasma membrane; receptor binding;
SPN	5	immune response; signal transduction; extracellular space; plasma membrane; integral to plasma membrane;

Genes shared at least 2 KEGG pathways with TNFSF15 (count: 0)

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Region: chr9:117551600..117568408 View in gBrowse