ADHDgene Database

Gene Report

Basic Info

Approved Symbol	SERPING1
Previous Symbol	C1NH
Symbol Alias	C1IN, C1-INH, HAE1, HAE2
Approved Name	serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
Previous Name	serine (or cysteine) proteinase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary)
Name Alias	plasma protease C1 inhibitor, "angioedema, hereditary"
Location	11q12-q13.1
Position	chr11:57364860-57382326, +
External Links	HGNC: 1228 Entrez Gene: 710 UCSC: uc001nkr.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0001869	negative regulation of complement activation, lectin pathway	Biological Process	IDA[10946292]	1
GO:0002576	platelet degranulation	Biological Process		12
GO:0004867	serine-type endopeptidase inhibitor activity	Molecular Function	IDA[11527969]	10
GO:0005515	protein binding	Molecular Function	IPI[10946292]	910
GO:0005576	extracellular region	Cellular Component	NAS[14718574]	240
GO:0005615	extracellular space	Cellular Component		126
GO:0006958	complement activation, classical pathway	Biological Process		6
GO:0007596	blood coagulation	Biological Process		83
GO:0007597	blood coagulation, intrinsic pathway	Biological Process		4
GO:0008015	blood circulation	Biological Process	TAS[2563376]	12
GO:0010951	negative regulation of endopeptidase activity	Biological Process		7
GO:0030168	platelet activation	Biological Process		38
GO:0031093	platelet alpha granule lumen	Cellular Component		5
GO:0045087	innate immune response	Biological Process		54
GO:0042730	fibrinolysis	Biological Process		1

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04610	Complement and coagulation cascades	12	The complement system is a proteolytic cascade in blood plas...... The complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation: the classical pathway, the lectin pathway, and the alternative pathway. All of these pathways generate a crucial enzymatic activity that, in turn, generates the effector molecules of complement. The main consequences of complement activation are the opsonization of pathogens, the recruitment of inflammatory and immunocompetent cells, and the direct killing of pathogens. Blood coagulation is another series of proenzyme-to-serine protease conversions, culminating the formation of thrombin, the enzyme responsible for the conversion of soluble fibrinogen to the insoluble fibrin clot. Protease-activated receptors, such as those activated by thrombin, are members of G protein-coupled receptors and function as a mediator of innate immunity. The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results in the release of vasoactive kinins (bradykinin-related peptides). Kinin peptides are implicated in many physiological and pathological processes including the regulation of blood pressure and sodium homeostasis, inflammatory processes, and the cardioprotective effects of preconditioning. More...

Genes shared at least 5 GO terms with SERPING1 (count: 7)

Gene Symbol	Pathway Count	Pathway List
FN1	7	platelet degranulation; protein binding; extracellular region; extracellular space; blood coagulation; platelet activation; platelet alpha granule lumen;
VEGFA	7	platelet degranulation; protein binding; extracellular region; extracellular space; blood coagulation; platelet activation; platelet alpha granule lumen;
VEGFB	7	platelet degranulation; protein binding; extracellular region; extracellular space; blood coagulation; platelet activation; platelet alpha granule lumen;
APOA1	6	platelet degranulation; protein binding; extracellular region; extracellular space; blood coagulation; platelet activation;
SERPINC1	6	serine-type endopeptidase inhibitor activity; protein binding; extracellular region; extracellular space; blood coagulation; negative regulation of endopeptidase activity;
ALDOA	5	platelet degranulation; extracellular region; blood coagulation; platelet activation; platelet alpha granule lumen;
HABP4	5	platelet degranulation; protein binding; extracellular region; blood coagulation; platelet activation;

Genes shared at least 2 KEGG pathways with SERPING1 (count: 0)

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Region: chr11:57364860..57382326 View in gBrowse