ADHDgene Database

Gene Report

Basic Info

Approved Symbol	SEC11C
Previous Symbol	SEC11L3
Symbol Alias	SPC21, SPCS4C
Approved Name	SEC11 homolog C (S. cerevisiae)
Previous Name	SEC11-like 3 (S. cerevisiae)
Location	18q21.32
Position	chr18:56807087-56826068, +
External Links	HGNC: 23400 Entrez Gene: 90701 Ensembl: ENSG00000166562 UCSC: uc002lht.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
18q21.31-21.32	chr18:53800000-59000000	1 (1/0/0)

Gene related GO terms (count: 12)

ID	Name	Type	No. of Genes in ADHDgene
GO:0008236	serine-type peptidase activity	Molecular Function	11
GO:0010467	gene expression	Biological Process	140
GO:0006508	proteolysis	Biological Process	102
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	Biological Process	18
GO:0044281	small molecule metabolic process	Biological Process	248
GO:0050796	regulation of insulin secretion	Biological Process	22
GO:0016021	integral to membrane	Cellular Component	845
GO:0044267	cellular protein metabolic process	Biological Process	64
GO:0006412	translation	Biological Process	42
GO:0006465	signal peptide processing	Biological Process	3
GO:0005789	endoplasmic reticulum membrane	Cellular Component	140
GO:0006112	energy reserve metabolic process	Biological Process	25

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03060	Protein export	7	The protein export is the active transport of proteins from ...... The protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the general protein export system that transports newly synthesized proteins into or across the cell membrane. The translocation channel is formed from a conserved trimeric membrane protein complex, called the Sec61/SecY complex. The twin-arginine translocation (Tat) pathway is another protein transport system that transports folded proteins in bacteria, archaea, and chloroplasts. Many Tat systems comprise three functionally different membrane proteins, TatA, TatB, and TatC, but TatA and TatE seem to have overlapping functions, with TatA having by far the more important role. More...

Genes shared at least 5 GO terms with SEC11C (count: 5)

Gene Symbol	Pathway Count	Pathway List
SPCS2	11	gene expression; proteolysis; SRP-dependent cotranslational protein targeting to membrane; small molecule metabolic process; regulation of insulin secretion; integral to membrane; cellular protein metabolic process; translation; signal peptide processing; endoplasmic reticulum membrane; energy reserve metabolic process;
SRPR	6	gene expression; SRP-dependent cotranslational protein targeting to membrane; integral to membrane; cellular protein metabolic process; translation; endoplasmic reticulum membrane;
SEC61B	5	gene expression; SRP-dependent cotranslational protein targeting to membrane; integral to membrane; cellular protein metabolic process; translation;
ITPR1	5	small molecule metabolic process; regulation of insulin secretion; integral to membrane; endoplasmic reticulum membrane; energy reserve metabolic process;
ITPR2	5	small molecule metabolic process; regulation of insulin secretion; integral to membrane; endoplasmic reticulum membrane; energy reserve metabolic process;

Genes shared at least 2 KEGG pathways with SEC11C (count: 0)

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Region: chr18:56807087..56826068 View in gBrowse