ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	RPP30
Symbol Alias	TSG15
Approved Name	ribonuclease P/MRP 30kDa subunit
Location	10q23.32-q23.33
Position	chr10:92631473-92668312, +
External Links	HGNC: 17688 Entrez Gene: 10556 Ensembl: ENSG00000148688 UCSC: uc001khd.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by LD-proxy

Gene related studies (count: 0)

Gene related SNPs (count: 11)

Literature-origin SNPs (count: 0)

LD-proxies (count: 11)

rs_ID	Location	Functional Annotation
rs10881844	Chr10:92648024(Fwd)	intron_variant; nc_transcript_variant
rs12246757	Chr10:92634383(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant
rs7101301	Chr10:92649923(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant
rs11186351	Chr10:92649784(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant
rs7909232	Chr10:92651479(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant
rs7896973	Chr10:92650797(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant
rs7900048	Chr10:92656513(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant
rs4933618	Chr10:92652571(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant
rs7089472	Chr10:92663108(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant
rs4568910	Chr10:92662860(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant
rs4522081	Chr10:92666683(Fwd)	3_prime_UTR_variant; downstream_gene_variant; intron_variant; nc_transcript_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 4)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 4)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005634	nucleus	Cellular Component	TAS[9630247]	770
GO:0005655	nucleolar ribonuclease P complex	Cellular Component	TAS[9630247]	1
GO:0008033	tRNA processing	Biological Process		11
GO:0004526	ribonuclease P activity	Molecular Function		1

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03008	Ribosome biogenesis in eukaryotes	12	Ribosomes are the cellular factories responsible for making ...... Ribosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It requires hundreds of factors not present in the mature particle. In the absence of these proteins, ribosome biogenesis is stalled and cell growth is terminated even under optimal growth conditions. The primary pre-rRNA transcript is assembled into the 90S pre-ribosome, which contains both 40S and 60S assembly factors. Within this complex, the pre-rRNA is cleaved. pre-60S ribosomes are subjected to several sequential processing steps in the nucleoplasm involving numerous assembly intermediates before it is exported to the cytoplasm and matured into the 60S ribosomal subunit. The pre-40S ribosome is matured to the small ribosomal subunit in the cytoplasm by cleavage. More...
hsa03013	RNA transport	15	RNA transport from the nucleus to the cytoplasm is fundamen...... RNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) via mobile export receptors. The majority of RNAs, such as tRNAs, rRNAs, and U snRNAs, are transported by specific export receptors, which belong to the karyopherin-beta family proteins. A feature of karyopherins is their regulation by the small GTPase Ran. However, general mRNA export is mechanistically different. Nuclear export of mRNAs is functionally coupled to different steps in gene expression processes, such as transcription, splicing, 3'-end formation and even translation. More...

Genes shared at least 5 GO terms with RPP30 (count: 0)

Genes shared at least 2 KEGG pathways with RPP30 (count: 5)

Gene Symbol	Pathway Count	Pathway List
C9orf23	2	Ribosome biogenesis in eukaryotes; RNA transport;
NMD3	2	Ribosome biogenesis in eukaryotes; RNA transport;
NXF1	2	Ribosome biogenesis in eukaryotes; RNA transport;
RAN	2	Ribosome biogenesis in eukaryotes; RNA transport;
XPO1	2	Ribosome biogenesis in eukaryotes; RNA transport;

View in gBrowse

Region: chr10:92631473..92668312 View in gBrowse