ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MED13
Previous Symbol	THRAP1
Symbol Alias	KIAA0593, TRAP240
Approved Name	mediator complex subunit 13
Previous Name	thyroid hormone receptor associated protein 1
Location	17q22-q23
Position	chr17:60019966-60142643, -
External Links	HGNC: 22474 Entrez Gene: 9969 Ensembl: ENSG00000108510 UCSC: uc002izo.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 17)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0035257	nuclear hormone receptor binding	Molecular Function		30

GO terms by database search (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0003712	transcription cofactor activity	Molecular Function	IDA[12218053]	17
GO:0003713	transcription coactivator activity	Molecular Function	IDA[12037571]	52
GO:0004872	receptor activity	Molecular Function	IDA[12218053]	36
GO:0005634	nucleus	Cellular Component	IDA[10235267]	770
GO:0001104	RNA polymerase II transcription cofactor activity	Molecular Function	IDA[10198638]	16
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	Molecular Function	NAS[10235266]	19
GO:0030518	intracellular steroid hormone receptor signaling pathway	Biological Process	IDA[11867769]	10
GO:0030521	androgen receptor signaling pathway	Biological Process	IDA[12218053]	16
GO:0005654	nucleoplasm	Cellular Component		183
GO:0006367	transcription initiation from RNA polymerase II promoter	Biological Process	IDA[12218053]	42
GO:0010467	gene expression	Biological Process		140
GO:0016592	mediator complex	Cellular Component	IDA[12037571]	17
GO:0042809	vitamin D receptor binding	Molecular Function	NAS[10235266]	11
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	IDA[10198638]	80
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IDA[12037571]	131
GO:0046966	thyroid hormone receptor binding	Molecular Function	IDA[10198638]	18

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with MED13 (count: 34)

Gene Symbol	Pathway Count	Pathway List
MED1	17	transcription cofactor activity; transcription coactivator activity; receptor activity; nucleus; RNA polymerase II transcription cofactor activity; ligand-dependent nuclear receptor transcription coactivator activity; intracellular steroid hormone receptor signaling pathway; androgen receptor signaling pathway; nuclear hormone receptor binding; nucleoplasm; transcription initiation from RNA polymerase II promoter; gene expression; mediator complex; vitamin D receptor binding; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; thyroid hormone receptor binding;
MED12	17	transcription cofactor activity; transcription coactivator activity; receptor activity; nucleus; RNA polymerase II transcription cofactor activity; ligand-dependent nuclear receptor transcription coactivator activity; intracellular steroid hormone receptor signaling pathway; androgen receptor signaling pathway; nuclear hormone receptor binding; nucleoplasm; transcription initiation from RNA polymerase II promoter; gene expression; mediator complex; vitamin D receptor binding; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; thyroid hormone receptor binding;
MED14	17	transcription cofactor activity; transcription coactivator activity; receptor activity; nucleus; RNA polymerase II transcription cofactor activity; ligand-dependent nuclear receptor transcription coactivator activity; intracellular steroid hormone receptor signaling pathway; androgen receptor signaling pathway; nuclear hormone receptor binding; nucleoplasm; transcription initiation from RNA polymerase II promoter; gene expression; mediator complex; vitamin D receptor binding; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; thyroid hormone receptor binding;
MED17	17	transcription cofactor activity; transcription coactivator activity; receptor activity; nucleus; RNA polymerase II transcription cofactor activity; ligand-dependent nuclear receptor transcription coactivator activity; intracellular steroid hormone receptor signaling pathway; androgen receptor signaling pathway; nuclear hormone receptor binding; nucleoplasm; transcription initiation from RNA polymerase II promoter; gene expression; mediator complex; vitamin D receptor binding; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; thyroid hormone receptor binding;
MED24	15	transcription cofactor activity; receptor activity; nucleus; RNA polymerase II transcription cofactor activity; ligand-dependent nuclear receptor transcription coactivator activity; intracellular steroid hormone receptor signaling pathway; androgen receptor signaling pathway; nuclear hormone receptor binding; nucleoplasm; transcription initiation from RNA polymerase II promoter; gene expression; mediator complex; vitamin D receptor binding; positive regulation of transcription, DNA-dependent; thyroid hormone receptor binding;
MED30	15	transcription cofactor activity; receptor activity; nucleus; RNA polymerase II transcription cofactor activity; ligand-dependent nuclear receptor transcription coactivator activity; intracellular steroid hormone receptor signaling pathway; androgen receptor signaling pathway; nuclear hormone receptor binding; nucleoplasm; transcription initiation from RNA polymerase II promoter; gene expression; mediator complex; vitamin D receptor binding; positive regulation of transcription, DNA-dependent; thyroid hormone receptor binding;
MED4	15	transcription cofactor activity; receptor activity; nucleus; RNA polymerase II transcription cofactor activity; ligand-dependent nuclear receptor transcription coactivator activity; intracellular steroid hormone receptor signaling pathway; androgen receptor signaling pathway; nuclear hormone receptor binding; nucleoplasm; transcription initiation from RNA polymerase II promoter; gene expression; mediator complex; vitamin D receptor binding; positive regulation of transcription, DNA-dependent; thyroid hormone receptor binding;
THRAP3	15	transcription cofactor activity; transcription coactivator activity; receptor activity; nucleus; RNA polymerase II transcription cofactor activity; ligand-dependent nuclear receptor transcription coactivator activity; intracellular steroid hormone receptor signaling pathway; androgen receptor signaling pathway; nuclear hormone receptor binding; transcription initiation from RNA polymerase II promoter; mediator complex; vitamin D receptor binding; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; thyroid hormone receptor binding;
MED16	14	transcription cofactor activity; transcription coactivator activity; receptor activity; nucleus; intracellular steroid hormone receptor signaling pathway; androgen receptor signaling pathway; nuclear hormone receptor binding; nucleoplasm; transcription initiation from RNA polymerase II promoter; gene expression; mediator complex; vitamin D receptor binding; positive regulation of transcription, DNA-dependent; thyroid hormone receptor binding;
NCOA6	9	transcription coactivator activity; nucleus; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; nucleoplasm; transcription initiation from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; thyroid hormone receptor binding;
SNW1	8	transcription coactivator activity; nucleus; nuclear hormone receptor binding; nucleoplasm; transcription initiation from RNA polymerase II promoter; gene expression; vitamin D receptor binding; positive regulation of transcription from RNA polymerase II promoter;
MAML1	6	transcription coactivator activity; nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter; gene expression; positive regulation of transcription from RNA polymerase II promoter;
MAML2	6	transcription coactivator activity; nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter; gene expression; positive regulation of transcription from RNA polymerase II promoter;
MED7	6	transcription coactivator activity; RNA polymerase II transcription cofactor activity; nucleoplasm; transcription initiation from RNA polymerase II promoter; gene expression; mediator complex;
NR5A1	6	transcription coactivator activity; nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter; gene expression; positive regulation of transcription from RNA polymerase II promoter;
NRIP1	6	transcription coactivator activity; nucleus; androgen receptor signaling pathway; nuclear hormone receptor binding; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
PRPF6	6	transcription coactivator activity; nucleus; nuclear hormone receptor binding; nucleoplasm; gene expression; positive regulation of transcription from RNA polymerase II promoter;
SMARCD3	6	transcription coactivator activity; nucleus; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; nucleoplasm; positive regulation of transcription, DNA-dependent;
YAP1	6	transcription coactivator activity; nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter; gene expression; positive regulation of transcription from RNA polymerase II promoter;
MED15	6	nucleus; RNA polymerase II transcription cofactor activity; nucleoplasm; transcription initiation from RNA polymerase II promoter; gene expression; mediator complex;
PPARGC1B	6	nucleus; RNA polymerase II transcription cofactor activity; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; mediator complex; positive regulation of transcription from RNA polymerase II promoter;
NSD1	5	transcription cofactor activity; nucleus; nuclear hormone receptor binding; positive regulation of transcription, DNA-dependent; thyroid hormone receptor binding;
KAT5	5	transcription coactivator activity; nucleus; androgen receptor signaling pathway; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
MED23	5	transcription coactivator activity; nucleoplasm; transcription initiation from RNA polymerase II promoter; gene expression; mediator complex;
RAN	5	transcription coactivator activity; androgen receptor signaling pathway; nucleoplasm; gene expression; positive regulation of transcription, DNA-dependent;
TAF10	5	transcription coactivator activity; nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter; gene expression;
ESRRA	5	nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter; gene expression; positive regulation of transcription from RNA polymerase II promoter;
HMGA1	5	nucleus; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; nucleoplasm; positive regulation of transcription, DNA-dependent;
MEN1	5	nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter; gene expression; positive regulation of transcription from RNA polymerase II promoter;
NCOR1	5	nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter; gene expression; thyroid hormone receptor binding;
NR4A2	5	nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter; gene expression; positive regulation of transcription from RNA polymerase II promoter;
RBM14	5	nucleus; RNA polymerase II transcription cofactor activity; ligand-dependent nuclear receptor transcription coactivator activity; mediator complex; positive regulation of transcription from RNA polymerase II promoter;
RBPJ	5	nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter; gene expression; positive regulation of transcription from RNA polymerase II promoter;
TP53BP1	5	nucleus; RNA polymerase II transcription cofactor activity; nucleoplasm; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;

Genes shared at least 2 KEGG pathways with MED13 (count: 0)

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Region: chr17:60019966..60142643 View in gBrowse