ADHDgene Database

Gene Report

Basic Info

Approved Symbol	HYOU1
Symbol Alias	ORP150, HSP12A, Grp170
Approved Name	hypoxia up-regulated 1
Name Alias	glucose-regulated protein 170
Location	11q23.1-q23.3
Position	chr11:118914896-118927940, -
External Links	HGNC: 16931 Entrez Gene: 10525 Ensembl: ENSG00000149428 UCSC: uc001pux.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 6)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005783	endoplasmic reticulum	Cellular Component	TAS[9020069]	100
GO:0005524	ATP binding	Molecular Function		228
GO:0006950	response to stress	Biological Process	TAS[9020069]	30
GO:0005788	endoplasmic reticulum lumen	Cellular Component		33
GO:0030968	endoplasmic reticulum unfolded protein response	Biological Process		16
GO:0006987	activation of signaling protein activity involved in unfolded protein response	Biological Process		13

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04141	Protein processing in endoplasmic reticulum	26	The endoplasmic reticulum (ER) is a subcellular organelle wh...... The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis. More...

Genes shared at least 5 GO terms with HYOU1 (count: 1)

Gene Symbol	Pathway Count	Pathway List
HSPA5	5	endoplasmic reticulum; ATP binding; endoplasmic reticulum lumen; endoplasmic reticulum unfolded protein response; activation of signaling protein activity involved in unfolded protein response;

Genes shared at least 2 KEGG pathways with HYOU1 (count: 0)

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Region: chr11:118914896..118927940 View in gBrowse