ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	GLUL
Previous Symbol	GLNS
Approved Name	glutamate-ammonia ligase
Previous Name	glutamate-ammonia ligase (glutamine synthase)
Name Alias	glutamine synthetase
Location	1q31
Position	chr1:182350839-182361341, -
External Links	HGNC: 4341 Entrez Gene: 2752 Ensembl: ENSG00000135821 UCSC: uc001gpd.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
1q25.3	chr1:180300000-185800000	1 (1/0/0)

Gene related GO terms (count: 27)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 27)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0001504	neurotransmitter uptake	Biological Process		3
GO:0000287	magnesium ion binding	Molecular Function		28
GO:0004356	glutamate-ammonia ligase activity	Molecular Function		2
GO:0004351	glutamate decarboxylase activity	Molecular Function		1
GO:0005524	ATP binding	Molecular Function		228
GO:0005739	mitochondrion	Cellular Component		183
GO:0005791	rough endoplasmic reticulum	Cellular Component		7
GO:0005829	cytosol	Cellular Component		447
GO:0006538	glutamate catabolic process	Biological Process		1
GO:0006542	glutamine biosynthetic process	Biological Process		2
GO:0007268	synaptic transmission	Biological Process		96
GO:0008283	cell proliferation	Biological Process	IDA[18662667]	60
GO:0008652	cellular amino acid biosynthetic process	Biological Process		1
GO:0009749	response to glucose stimulus	Biological Process		10
GO:0016595	glutamate binding	Molecular Function		3
GO:0030145	manganese ion binding	Molecular Function		10
GO:0032024	positive regulation of insulin secretion	Biological Process		5
GO:0034641	cellular nitrogen compound metabolic process	Biological Process		30
GO:0042802	identical protein binding	Molecular Function		70
GO:0043204	perikaryon	Cellular Component		12
GO:0051968	positive regulation of synaptic transmission, glutamatergic	Biological Process		8
GO:0051260	protein homooligomerization	Biological Process		34
GO:0050679	positive regulation of epithelial cell proliferation	Biological Process		9
GO:0045503	dynein light chain binding	Molecular Function		1
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0043679	axon terminus	Cellular Component		6
GO:0043234	protein complex	Cellular Component		45

Gene related KEGG pathways (count: 5)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa01100	Metabolic pathways	237
hsa00330	Arginine and proline metabolism	13
hsa04724	Glutamatergic synapse	43	Glutamate is the major excitatory neurotransmitter in the ma...... Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synaptic cleft, glutamate acts on postsynaptic ionotropic glutamate receptors (iGluRs) to mediate fast excitatory synaptic transmission. Glutamate can also act on metabotropic glutamate receptors (mGluRs) and exert a variety of modulatory effects through their coupling to G proteins and the subsequent recruitment of second messenger systems. Presynaptically localized Group II and Group III mGluRs are thought to represent the classical inhibitory autoreceptor mechanism that suppresses excess glutamate release. After its action on these receptors, glutamate can be removed from the synaptic cleft by EAATs located either on the presynaptic terminal, neighboring glial cells, or the postsynaptic neuron. In glia, glutamate is converted to glutamine, which is then transported back to the presynaptic terminal and converted back to glutamate. More...
hsa00910	Nitrogen metabolism	6
hsa00250	Alanine, aspartate and glutamate metabolism	4

Genes shared at least 5 GO terms with GLUL (count: 7)

Gene Symbol	Pathway Count	Pathway List
MAPK1	6	ATP binding; mitochondrion; cytosol; synaptic transmission; perikaryon; protein complex;
COMT	5	magnesium ion binding; mitochondrion; cytosol; synaptic transmission; small molecule metabolic process;
SNCA	5	magnesium ion binding; mitochondrion; rough endoplasmic reticulum; cytosol; identical protein binding;
PRKD1	5	ATP binding; cytosol; cell proliferation; identical protein binding; small molecule metabolic process;
RIPK3	5	ATP binding; mitochondrion; cytosol; identical protein binding; protein homooligomerization;
BAD	5	mitochondrion; cytosol; response to glucose stimulus; positive regulation of insulin secretion; positive regulation of epithelial cell proliferation;
TH	5	mitochondrion; cytosol; cellular nitrogen compound metabolic process; perikaryon; small molecule metabolic process;

Genes shared at least 2 KEGG pathways with GLUL (count: 26)

Gene Symbol	Pathway Count	Pathway List
AGXT2	2	Metabolic pathways; Alanine, aspartate and glutamate metabolism;
ALDH3A2	2	Metabolic pathways; Arginine and proline metabolism;
ARG1	2	Metabolic pathways; Arginine and proline metabolism;
CKMT1A	2	Metabolic pathways; Arginine and proline metabolism;
CKMT1B	2	Metabolic pathways; Arginine and proline metabolism;
GFPT2	2	Metabolic pathways; Alanine, aspartate and glutamate metabolism;
MAOA	2	Metabolic pathways; Arginine and proline metabolism;
MAOB	2	Metabolic pathways; Arginine and proline metabolism;
NOS1	2	Metabolic pathways; Arginine and proline metabolism;
ODC1	2	Metabolic pathways; Arginine and proline metabolism;
P4HA3	2	Metabolic pathways; Arginine and proline metabolism;
PLA2G10	2	Metabolic pathways; Glutamatergic synapse;
PLA2G1B	2	Metabolic pathways; Glutamatergic synapse;
PLA2G2A	2	Metabolic pathways; Glutamatergic synapse;
PLA2G2D	2	Metabolic pathways; Glutamatergic synapse;
PLA2G2E	2	Metabolic pathways; Glutamatergic synapse;
PLA2G3	2	Metabolic pathways; Glutamatergic synapse;
PLA2G4B	2	Metabolic pathways; Glutamatergic synapse;
PLA2G5	2	Metabolic pathways; Glutamatergic synapse;
PLA2G6	2	Metabolic pathways; Glutamatergic synapse;
PLCB2	2	Metabolic pathways; Glutamatergic synapse;
PLCB3	2	Metabolic pathways; Glutamatergic synapse;
PLD1	2	Metabolic pathways; Glutamatergic synapse;
PLD2	2	Metabolic pathways; Glutamatergic synapse;
PRODH	2	Metabolic pathways; Arginine and proline metabolism;
PYCRL	2	Metabolic pathways; Arginine and proline metabolism;

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Region: chr1:182350839..182361341 View in gBrowse