ADHDgene Database

Gene Report

Basic Info

Approved Symbol	DROSHA
Previous Symbol	RNASEN
Symbol Alias	RNASE3L, Etohi2, HSA242976, RN3
Approved Name	drosha, ribonuclease type III
Previous Name	ribonuclease type III, nuclear
Name Alias	drosha, ribonuclease type III, "drosha, double-stranded RNA-specific endoribonuclease"
Location	5q11.2
Position	chr5:31400601-31532303, -
External Links	HGNC: 17904 Entrez Gene: 29102 Ensembl: ENSG00000113360 UCSC: uc003jhg.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
5p13	chr5:28900000-42500000	3 (1/1/1)

Gene related GO terms (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0004525	ribonuclease III activity	Molecular Function		1
GO:0005515	protein binding	Molecular Function	IPI[15574589]	910
GO:0005654	nucleoplasm	Cellular Component		183
GO:0005730	nucleolus	Cellular Component		243
GO:0010467	gene expression	Biological Process		140
GO:0010586	miRNA metabolic process	Biological Process		1
GO:0016075	rRNA catabolic process	Biological Process		2
GO:0031054	pre-miRNA processing	Biological Process		1
GO:0042254	ribosome biogenesis	Biological Process		5
GO:0003725	double-stranded RNA binding	Molecular Function		6
GO:0046872	metal ion binding	Molecular Function		170

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03008	Ribosome biogenesis in eukaryotes	12	Ribosomes are the cellular factories responsible for making ...... Ribosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It requires hundreds of factors not present in the mature particle. In the absence of these proteins, ribosome biogenesis is stalled and cell growth is terminated even under optimal growth conditions. The primary pre-rRNA transcript is assembled into the 90S pre-ribosome, which contains both 40S and 60S assembly factors. Within this complex, the pre-rRNA is cleaved. pre-60S ribosomes are subjected to several sequential processing steps in the nucleoplasm involving numerous assembly intermediates before it is exported to the cytoplasm and matured into the 60S ribosomal subunit. The pre-40S ribosome is matured to the small ribosomal subunit in the cytoplasm by cleavage. More...

Genes shared at least 5 GO terms with DROSHA (count: 2)

Gene Symbol	Pathway Count	Pathway List
DGCR8	6	protein binding; nucleoplasm; nucleolus; gene expression; double-stranded RNA binding; metal ion binding;
DHX9	5	protein binding; nucleoplasm; nucleolus; gene expression; double-stranded RNA binding;

Genes shared at least 2 KEGG pathways with DROSHA (count: 0)

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Region: chr5:31400601..31532303 View in gBrowse