ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	DHX8
Previous Symbol	DDX8
Symbol Alias	HRH1, PRP22, PRPF22
Approved Name	DEAH (Asp-Glu-Ala-His) box polypeptide 8
Previous Name	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 8 (RNA helicase)
Location	17q21.31
Position	chr17:41561334-41601680, +
External Links	HGNC: 2749 Entrez Gene: 1659 Ensembl: ENSG00000067596 UCSC: uc002idu.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 11)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005681	spliceosomal complex	Cellular Component	TAS[7935475]	51

GO terms by database search (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005634	nucleus	Cellular Component		770
GO:0005524	ATP binding	Molecular Function		228
GO:0005730	nucleolus	Cellular Component		243
GO:0003723	RNA binding	Molecular Function		104
GO:0000398	mRNA splicing, via spliceosome	Biological Process	IC[11991638]	54
GO:0005515	protein binding	Molecular Function	IPI[16820410]	910
GO:0004004	ATP-dependent RNA helicase activity	Molecular Function	TAS[7935475]	5
GO:0006396	RNA processing	Biological Process	TAS[7935475]	11
GO:0008380	RNA splicing	Biological Process	TAS[7935475]	65
GO:0071013	catalytic step 2 spliceosome	Cellular Component	IDA[11991638]	31

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03040	Spliceosome	47	After transcription, eukaryotic mRNA precursors contain prot...... After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified. More...

Genes shared at least 5 GO terms with DHX8 (count: 45)

Gene Symbol	Pathway Count	Pathway List
DDX23	9	nucleus; ATP binding; nucleolus; spliceosomal complex; mRNA splicing, via spliceosome; protein binding; ATP-dependent RNA helicase activity; RNA splicing; catalytic step 2 spliceosome;
HNRNPA2B1	8	nucleus; nucleolus; spliceosomal complex; RNA binding; mRNA splicing, via spliceosome; protein binding; RNA splicing; catalytic step 2 spliceosome;
HNRNPH1	8	nucleus; nucleolus; RNA binding; mRNA splicing, via spliceosome; protein binding; RNA processing; RNA splicing; catalytic step 2 spliceosome;
SF3A1	8	nucleus; nucleolus; spliceosomal complex; RNA binding; mRNA splicing, via spliceosome; protein binding; RNA splicing; catalytic step 2 spliceosome;
SNRNP200	8	nucleus; ATP binding; nucleolus; spliceosomal complex; mRNA splicing, via spliceosome; protein binding; RNA splicing; catalytic step 2 spliceosome;
U2AF1	8	nucleus; nucleolus; spliceosomal complex; RNA binding; mRNA splicing, via spliceosome; protein binding; RNA splicing; catalytic step 2 spliceosome;
DHX9	7	nucleus; ATP binding; nucleolus; mRNA splicing, via spliceosome; protein binding; ATP-dependent RNA helicase activity; RNA splicing;
EFTUD2	7	nucleus; nucleolus; spliceosomal complex; mRNA splicing, via spliceosome; protein binding; RNA splicing; catalytic step 2 spliceosome;
HNRNPA1	7	nucleus; nucleolus; spliceosomal complex; RNA binding; mRNA splicing, via spliceosome; RNA splicing; catalytic step 2 spliceosome;
PRPF4	7	nucleus; nucleolus; spliceosomal complex; mRNA splicing, via spliceosome; protein binding; RNA processing; RNA splicing;
PRPF6	7	nucleus; spliceosomal complex; RNA binding; mRNA splicing, via spliceosome; protein binding; RNA splicing; catalytic step 2 spliceosome;
SF3A3	7	nucleus; nucleolus; spliceosomal complex; mRNA splicing, via spliceosome; protein binding; RNA splicing; catalytic step 2 spliceosome;
CWC15	6	nucleus; spliceosomal complex; RNA binding; mRNA splicing, via spliceosome; protein binding; catalytic step 2 spliceosome;
DDX54	6	nucleus; ATP binding; nucleolus; RNA binding; ATP-dependent RNA helicase activity; RNA processing;
FUS	6	nucleus; nucleolus; RNA binding; mRNA splicing, via spliceosome; protein binding; RNA splicing;
HSPA8	6	nucleus; ATP binding; nucleolus; spliceosomal complex; protein binding; RNA splicing;
RBM4	6	nucleus; nucleolus; RNA binding; protein binding; RNA processing; RNA splicing;
SF3B2	6	nucleus; nucleolus; spliceosomal complex; mRNA splicing, via spliceosome; RNA splicing; catalytic step 2 spliceosome;
SMC1A	6	nucleus; ATP binding; nucleolus; mRNA splicing, via spliceosome; protein binding; RNA splicing;
SNRPD1	6	nucleus; RNA binding; mRNA splicing, via spliceosome; protein binding; RNA splicing; catalytic step 2 spliceosome;
SNW1	6	nucleus; nucleolus; spliceosomal complex; mRNA splicing, via spliceosome; protein binding; catalytic step 2 spliceosome;
HNRNPC	6	spliceosomal complex; RNA binding; mRNA splicing, via spliceosome; protein binding; RNA splicing; catalytic step 2 spliceosome;
PRPF8	6	spliceosomal complex; RNA binding; mRNA splicing, via spliceosome; protein binding; RNA splicing; catalytic step 2 spliceosome;
SNRPA1	6	spliceosomal complex; RNA binding; mRNA splicing, via spliceosome; protein binding; RNA splicing; catalytic step 2 spliceosome;
SNRPG	6	spliceosomal complex; RNA binding; mRNA splicing, via spliceosome; protein binding; RNA splicing; catalytic step 2 spliceosome;
CDK12	5	nucleus; ATP binding; nucleolus; protein binding; RNA splicing;
CPSF7	5	nucleus; RNA binding; mRNA splicing, via spliceosome; protein binding; RNA splicing;
DHX15	5	nucleus; ATP binding; nucleolus; spliceosomal complex; RNA splicing;
NCBP1	5	nucleus; RNA binding; mRNA splicing, via spliceosome; protein binding; RNA splicing;
NOVA1	5	nucleus; RNA binding; mRNA splicing, via spliceosome; RNA processing; RNA splicing;
SART1	5	nucleus; nucleolus; mRNA splicing, via spliceosome; protein binding; catalytic step 2 spliceosome;
SCAF8	5	nucleus; nucleolus; spliceosomal complex; RNA binding; RNA splicing;
SF1	5	nucleus; nucleolus; spliceosomal complex; RNA binding; mRNA splicing, via spliceosome;
SLU7	5	nucleus; nucleolus; spliceosomal complex; mRNA splicing, via spliceosome; catalytic step 2 spliceosome;
SMNDC1	5	nucleus; spliceosomal complex; RNA binding; protein binding; RNA splicing;
TARDBP	5	nucleus; nucleolus; RNA binding; protein binding; RNA splicing;
THRAP3	5	nucleus; ATP binding; nucleolus; protein binding; RNA splicing;
SF3B4	5	spliceosomal complex; RNA binding; mRNA splicing, via spliceosome; protein binding; RNA splicing;
SNRPA	5	spliceosomal complex; RNA binding; mRNA splicing, via spliceosome; protein binding; RNA splicing;
SNRPB	5	spliceosomal complex; mRNA splicing, via spliceosome; protein binding; RNA splicing; catalytic step 2 spliceosome;
SNRPB2	5	spliceosomal complex; mRNA splicing, via spliceosome; protein binding; RNA splicing; catalytic step 2 spliceosome;
SNRPD2	5	spliceosomal complex; mRNA splicing, via spliceosome; protein binding; RNA splicing; catalytic step 2 spliceosome;
SNRPD3	5	spliceosomal complex; mRNA splicing, via spliceosome; protein binding; RNA splicing; catalytic step 2 spliceosome;
SNRPF	5	spliceosomal complex; RNA binding; mRNA splicing, via spliceosome; RNA splicing; catalytic step 2 spliceosome;
U2AF2	5	spliceosomal complex; RNA binding; mRNA splicing, via spliceosome; protein binding; RNA splicing;

Genes shared at least 2 KEGG pathways with DHX8 (count: 0)

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Region: chr17:41561334..41601680 View in gBrowse