ADHDgene Database

Gene Report

Basic Info

Approved Symbol	CHMP4A
Previous Symbol	C14orf123
Symbol Alias	HSPC134, VPS32A
Approved Name	chromatin modifying protein 4A
Previous Name	chromosome 14 open reading frame 123
Location	14q11.2
Position	chr14:24678787-24683185, -
External Links	HGNC: 20274 Entrez Gene: 29082 Ensembl: ENSG00000100931
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
14q12	chr14:24600000-33300000	1 (1/0/0)

Gene related GO terms (count: 7)

ID	Name	Type	No. of Genes in ADHDgene
GO:0008289	lipid binding	Molecular Function	23
GO:0005829	cytosol	Cellular Component	447
GO:0016197	endosomal transport	Biological Process	11
GO:0030659	cytoplasmic vesicle membrane	Cellular Component	18
GO:0015031	protein transport	Biological Process	75
GO:0016044	cellular membrane organization	Biological Process	24
GO:0031902	late endosome membrane	Cellular Component	15

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04144	Endocytosis	39	Endocytosis is a mechanism for cells to remove ligands, nutr...... Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type. More...

Genes shared at least 5 GO terms with CHMP4A (count: 0)

Genes shared at least 2 KEGG pathways with CHMP4A (count: 0)

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Region: chr14:24678787..24683185 View in gBrowse