ADHDgene Database

Gene Report

Basic Info

Approved Symbol	CDC42EP2
Symbol Alias	CEP2, BORG1
Approved Name	CDC42 effector protein (Rho GTPase binding) 2
Name Alias	CRIB-containing BOGR1 protein
Location	11q13
Position	chr11:65082289-65089900, +
External Links	HGNC: 16263 Entrez Gene: 10435 Ensembl: ENSG00000149798 UCSC: uc001odl.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway; Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0051493	regulation of cytoskeleton organization	Biological Process		32

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005515	protein binding	Molecular Function	IPI[11584266]	910
GO:0005100	Rho GTPase activator activity	Molecular Function	IMP[10430899]	6
GO:0001515	opioid peptide activity	Molecular Function		1
GO:0032321	positive regulation of Rho GTPase activity	Biological Process	IMP[10430899]	6
GO:0031274	positive regulation of pseudopodium assembly	Biological Process	IDA[11035016]	3
GO:0031334	positive regulation of protein complex assembly	Biological Process	TAS[11584266]	4
GO:0030036	actin cytoskeleton organization	Biological Process	IDA[10430899]	21
GO:0030838	positive regulation of actin filament polymerization	Biological Process	IDA[11035016]	9
GO:0016020	membrane	Cellular Component	IDA[11035016]	139
GO:0017049	GTP-Rho binding	Molecular Function	IPI[11035016]	3
GO:0012505	endomembrane system	Cellular Component		16
GO:0015630	microtubule cytoskeleton	Cellular Component		34
GO:0007015	actin filament organization	Biological Process	NAS[11035016]	12
GO:0008360	regulation of cell shape	Biological Process	IDA[11035016]	20
GO:0005737	cytoplasm	Cellular Component		690
GO:0005886	plasma membrane	Cellular Component	IDA[10430899]	772

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with CDC42EP2 (count: 8)

Gene Symbol	Pathway Count	Pathway List
CDC42EP5	9	regulation of cytoskeleton organization; positive regulation of pseudopodium assembly; positive regulation of actin filament polymerization; membrane; GTP-Rho binding; endomembrane system; regulation of cell shape; cytoplasm; plasma membrane;
CORO1A	6	protein binding; actin cytoskeleton organization; actin filament organization; regulation of cell shape; cytoplasm; plasma membrane;
NCK1	6	protein binding; regulation of cytoskeleton organization; positive regulation of actin filament polymerization; actin filament organization; cytoplasm; plasma membrane;
APC	5	protein binding; regulation of cytoskeleton organization; positive regulation of pseudopodium assembly; cytoplasm; plasma membrane;
ARF6	5	protein binding; regulation of cytoskeleton organization; positive regulation of actin filament polymerization; membrane; plasma membrane;
NCK2	5	protein binding; regulation of cytoskeleton organization; positive regulation of actin filament polymerization; actin filament organization; cytoplasm;
NF2	5	protein binding; regulation of cytoskeleton organization; actin cytoskeleton organization; cytoplasm; plasma membrane;
VEGFA	5	protein binding; positive regulation of protein complex assembly; membrane; regulation of cell shape; cytoplasm;

Genes shared at least 2 KEGG pathways with CDC42EP2 (count: 0)

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Region: chr11:65082289..65089900 View in gBrowse