Gene Report
Basic Info
Approved Symbol |
ARAP1
|
Previous Symbol |
CENTD2 |
Approved Name |
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 |
Previous Name |
centaurin, delta 2 |
Location |
11q13.3 |
Position |
chr11:72396114-72463448, - |
External Links |
HGNC: 16925
Entrez Gene: 116985
Ensembl: ENSG00000186635
UCSC: uc001osu.2
|
No. of Studies |
0 (significant: 0; non-significant: 0; trend: 0) |
Source |
Mapped by significant region |
Gene related studies (count: 0)
Gene related SNPs (count: 0)
Gene related CNVs (count: 0)
Gene related other variant (count: 0)
Gene related regions (count: 1)
Gene related GO terms (count: 18)
Gene related KEGG pathways (count: 1)
ID |
Name |
No. of Genes in ADHDgene |
Brief Description |
hsa04144 |
Endocytosis |
39 |
Endocytosis is a mechanism for cells to remove ligands, nutr......
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
More...
|
Genes shared at least 5 GO terms with ARAP1 (count: 7)
Genes shared at least 2 KEGG pathways with ARAP1 (count: 0)
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